Alpha 1 acid glycoprotein
Orosomucoid (ORM) or alpha-1-acid glycoprotein (AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein). Plasma levels are affected by pregnancy, certain drugs, and certain diseases, particularly HIV.
The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic drugs (whereas albumin carries acidic drugs), steroids, and protease inhibitors. Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal.
Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five-year risk of all-cause mortality (the other three are albumin, very low-density lipoprotein particle size, and citrate).
Orosomucoid increases in amount in obstructive jaundices while diminishes in hepatocellular jaundice and in intestinal infections.

This is an excerpt from the article Alpha 1 acid glycoprotein from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
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Orosomucoid - Wikipedia, the free encyclopedia
Orosomucoid (ORM) or alpha-1-acid glycoprotein (AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated ...
en.wikipedia.org/wiki/Orosomucoid
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Alpha-1-acid glycoprotein.
Biochim Biophys Acta. 2000 Oct 18;1482(1-2):157-71. Alpha-1-acid glycoprotein. Fournier T, Medjoubi-N N, Porquet D. INSERM U427, Faculté des Sciences ...
www.ncbi.nlm.nih.gov/pubmed/11058758
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Alpha-1-acid glycoprotein 1 precursor - Homo sapiens (Human)
Function. Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and ...
www.uniprot.org/uniprot/P02763
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alpha 1-Acid Glycoprotein - R&D Systems - Products
Results 1 - 6 of 6 ... Alpha-1-acid Glycoprotein is an acute-phase serum protein that is produced by the liver in response to inflammation and infection. It is a 183 ...
www.rndsystems.com/product_results.aspx?m=3267
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Alpha-1 Acid Glycoprotein AAG :: IVD Reagent - SDIX
Alpha-1-acid glycoprotein, also known as orosomucoid, is a member of the alpha -globulin family of proteins found in human serum. It binds many basic drugs ...
www.sdix.com/Products/IVD-Solutions/SDIX-Owned-IVD-Analytes/Alpha-1-Acid-Glycoprotein-AAG.aspx
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DrugBank: Alpha-1-acid glycoprotein 1
ID, 1181. Name, Alpha-1-acid glycoprotein 1. Synonyms. AGP 1; Orosomucoid-1; OMD 1; Alpha-1-acid glycoprotein 1 precursor. Gene Name, ORM1.
www.drugbank.ca/molecules/1181
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α 1 -Acid Glycoprotein from human plasma - Sigma-Aldrich
A simple method for the large-scale preparation of alpha1-acid glycoprotein. Hao , Y.L. and Wickerhauser, M. Biochim. Biophys. Acta 322, 99, (1973). Loading.
www.sigmaaldrich.com/catalog/product/sigma/g9885?lang=en®ion=US
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Alpha 1 acid Glycoprotein (AGP) Human ELISA Kit (ab108854 ...
Abcam's Alpha 1 acid glycoprotein (AGP) Human in vitro competitive ELISA ( Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitive ...
www.abcam.com/alpha-1-acid-glycoprotein-agp-human-elisa-kit-ab108854.html
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Alpha-1-acid glycoprotein 1 (Cytokines & Cells Encyclopedia - COPE)
Alpha-1-acid glycoprotein 1. abbr. AGP or AGP1 [alpha-1-AGP]. Approved gene symbol ORM1 [orosomucoid 1]). This protein has been identified originally as ...
www.copewithcytokines.org/cope.cgi?key=Alpha-1-acid%20glycoprotein%201
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IPR001500 - This URL has changed, please update your bookmarks ...
Alpha-1-acid glycoprotein (IPR001500) < InterPro < EMBL-EBI. Proteins matched (73). Domain organisations (3). Pathways & interactions. Species. Structures.
www.ebi.ac.uk/interpro/IEntry?ac=IPR001500
Search results for "Alpha 1 acid glycoprotein"
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Alpha 1 acid glycoprotein in science
Relationship between α1-acid glycoprotein and lidocaine ...
1-acid glycoprotein and lidocaine disposition in myocardial infarction ... Divisions of Clinical Pharmacology and Cardiology, Duke University Medical Center ... measured 12, 24, 36, and 48 hr after beginning therapy and were related to alpha ...
Changes in the binding capacity of alpha-1-acid glycoprotein in ...
Department of Pharmacy, Hokkaido University Hospital, Hokkaido University, Sapporo, Japan. The elevation of alpha-1-acid glycoprotein (AAG) concentration ...
Purification method for alpha-1-acid glycoprotein with subsequent ...
Department of Pharmacy, Hokkaido University Hospital, School of Medicine, ... A simple purification method for human plasma alpha-1-acid glycoprotein (AAG) ...
Alpha(1)-acid glycoprotein: an acute phase protein with ...
alpha(1)-Acid glycoprotein (AGP) is a protein with a molecular weight of 41-43 kDa and is heavily glycosylated (45%). Due to the presence of sialic acids, it is ...
In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the ...
Jan 19, 2012 ... 4Department of Medicine, McMaster University, Hamilton, ON, L8N 3Z5, ... Alpha-1 acid glycoprotein (AGP) is a highly glycosylated plasma ...
Protection by alpha 1-acid glycoprotein against tumor necrosis factor ...
Oct 1, 1994 ... The Rockefeller University Press, doi: 10.1084/jem.180.4.1571 ... We here report that alpha 1-acid glycoprotein, a typical acute phase protein, ...
Elevated Alpha-1-Acid Glycoprotein Reduces the Volume of ...
Mar 1, 2001 ... The results of this study show that alpha-1-acid glycoprotein is the ... in heparinized blood tubes at the University of Liverpool, Liverpool, ...
[PDF]Acute-Phase Proteins: Alpha -1- Acid Glycoprotein - InTech
Alpha -1- Acid Glycoprotein. C. Tesseromatis1, A. Alevizou2, E. Tigka1 and A. Kotsiou3. 1Department of Pharmacology, Medical School, University of Athens.
α1-Acid Glycoprotein Up-regulates CD163 via TLR4/CD14 Protein ...
Aug 31, 2012 ... the **Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto ... Results: α1-Acid glycoprotein (AGP) activates the toll-like ...
The binding ability of alpha-1-acid glycoprotein as a mechanism of ...
May 26, 2011 ... PhD thesis, Edinburgh Napier University. ... Certain plasma proteins including alpha1-acid glycoprotein (AGP) bind to drugs which causes ...
Books on the term Alpha 1 acid glycoprotein
Alpha-Globulins—Advances in Research and Application: 2013 ...
Alpha-Globulins—Advances in Research and Application: 2013 ...
2013
In addition, active fragments of zinc charged alpha 1-acid glycoprotein and alpha 2-HS glycoprotein, whether manufactured from the modification of natural alpha 1 -acid glycoprotein or alpha 2-HS glycoprotein, recombinantly, or synthetically, ...
Biomarkers in Multiple Sclerosis
Biomarkers in Multiple Sclerosis
U. Utz, 2006
These include alpha- 1 -antitrypsin, alpha- 1 -acid glycoprotein, haptoglobin. transferrin. and transthyretin. Interestingly, studies that have associated these molecules with MS have been reported: Proteases and their inhibitors have been  ...
Applied Pharmacokinetics & Pharmacodynamics: Principles of ...
Applied Pharmacokinetics & Pharmacodynamics: Principles of ...
Michael E. Burton, 2006
Importance of alpha 1-acid glycoprotein for interindividual variation. Clin Pharmacol Ther 1977:22: 545-549. 109. Baruzzi A. Contin M, Perucca E, et al. Altered serum protein binding of carbamaze- pine in disease states associated with an ...
Handbook of Toxicogenomics: A Strategic View of Current Research ...
Handbook of Toxicogenomics: A Strategic View of Current Research ...
Jürgen Borlak, 2006
NFkappaB and a 140-kDa phosphoprotein named Nopp140 interact with different C/EBP-beta isoforms that are activators for the alpha-1 acid glycoprotein gene. Known inducers of NfkappaB, such as IL-1beta and IL-6, can selectively activate ...
Genatlas
Genatlas
Molecular cloning and nucleotide sequence of human alpha-1 acid glycoprotein cDNA. Gene 44 : 127-131. (1986). Cox DW, Francke, U. Direct assignment of orosomucoid to human chromosome 9 and alpha-2HS-glycoprotein to chromosome ...
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Blog posts on the term
Alpha 1 acid glycoprotein
In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall
BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology) is a peer-reviewed, open access journal that publishes original research articles as well as review articles in several areas of life sciences. The journal’s Editorial Board is divided into the 55 subject areas included within the journal’s scope.
www.hindawi.com/journals/bmri/2012/292730/
Stratech Scientific's Blog: Alpha 1-Acid Glycoprotein ELISA
The Alpha 1-Acid Glycoprotein ELISA is a highly sensitive two-site enzyme linked immunoassay (ELISA) for measuring AGP in the biological fluids of humans. Acute phase proteins are plasma proteins which increase in concentration following infection, inflammation or trauma.
stratechuk.blogspot.com/2013/04/alpha-1-acid-glycoprotein-elisa.html
Proteome Science | Full text | The orosomucoid 1 protein (alpha1 acid glycoprotein) is overexpressed in odontogenic myxoma
Odontogenic myxoma (OM) is a benign, but locally invasive, neoplasm occurring in the jaws. However, the molecules implicated in its development are unknown. OM as well as Dental Follicle (DF), an odontogenic tissue surrounding the enamel organ, is derived from ectomesenchymal/mesencyhmal elements. To identify some protein that could participate in the development of this neoplasm, total proteins from OM were separated by two-dimensional electrophoresis and the profiles were compared with those obtained from DF, used as a control.
www.proteomesci.com/content/10/1/49
Comparison of Methods for the Purification of Alpha-1 Acid Glycoprotein from Human Plasma
BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology) is a peer-reviewed, open access journal that publishes original research articles as well as review articles in several areas of life sciences. The journal’s Editorial Board is divided into the 55 subject areas included within the journal’s scope.
www.hindawi.com/journals/bmri/2011/578207/
Product Focus: Alpha 1-Acid Glycoprotein ELISA | Stratech Scientific
The Alpha 1-Acid Glycoprotein ELISA is a highly sensitive two-site enzyme linked immunoassay (ELISA) for measuring AGP in the biological fluids of humans. Acute phase proteins are plasma proteins which increase in concentration following infection, inflammation or trauma. The first acute phase protein to be recognized was discovered in humans by Tillet and Frances in…
blog.stratech.co.uk/2013/03/18/product-focus-alpha-1-acid-glycoprotein-elisa/
α1-Acid Glycoprotein Up-regulates CD163 via TLR4/CD14 Protein Pathway
www.jbc.org/content/287/36/30688.abstract
Urinary monocyte chemoattractant protein 1 and alpha 1 acid glycoprotein as biomarkers of renal disease activity in juvenile-onset systemic lupus erythematosus
lup.sagepub.com/content/21/5/496.abstract
» Study Links High Iron Levels to Heart Disease Plaques | Natural Health Research Institute – NHRI
www.naturalhealthresearch.org/nhri/study-links-high-iron-levels-to-heart-disease-plaques/
Proteins: alpha-1 acid glycoprotein
Alpha-1-acid glycoprotein (AGP) or orosomucoid (ORM) is an acute phase protein synthesized in response to pro-inflammatory cytokines early in the inflammatory response. AGP gene expression is controlled by a combination of the major regulatory mediators – glucocorticoids and a cytokine network involving IL-1β, TNF-α, IL-6, and IL-6 related cytokines.
proteian.blogspot.com/2007/12/alpha-1-acid-glycoprotein.html
"Characterization of drug interactions with alpha1-acid glycoprotein us" by Hai Xuan
This dissertation focuses on characterization of drug interactions with α 1-acid glycoprotein (AGP) using high performance affinity chromatography (HPAC). The first part examines the interactions between propranolol and AGP using hydrazide-linked AGP supports in HPAC columns. The binding of R- and S-propranolol to a hydrazide-linked AGP column was evaluated by zonal elution and frontal analysis. The results indicated that propranolol had a single binding site on AGP with association constants of 0.8 (±0.2) × 106 M-1 for R-propranolol and 1.0 (±0.1) × 106 M -1 for S-propranolol at pH 7.4 and 37°C. The results confirm that a hydrazide-linked AGP column can be used as a model for soluble AGP in this system. This work also examined the ability of drug screening on the AGP column and a good correlation (correlation coefficient of 0.954) between the retentions in the HPLC system and the association constants from the literatures for 11 drugs was observed. ^ Part two examines the applications of hydrazide-linked AGP supports in chiral separations by using R- and S-propranolol as model solutes. The effects of various chromatographic conditions were examined in this work including temperature, mobile buffer pH, ionic strength and organic modifier. Finally, the chromatographic conditions used to separate R- and S-propranolol on the hydrazide-linked AGP column was optimized. Under the final optimized conditions identified in this study it was possible to separate R- and S-propranolol with a resolution of 1.38 in less than 5 min. ^ Part three examined the interactions between carbamazepine and AGP using hydrazide-linked AGP columns. Equations for a two-site binding system were derived for both frontal analysis and zonal elution. In general, two classes of binding sites for carbamazepine were found on the AGP column with association equilibrium constants that ranged from 0.7 to 3.1 × 106 M-1 between 5 and 45°C for high affinity site and 1.9 to 7.8 × 104 M-1 for the low affinity sites. It was also found that the higher affinity site made up an average of 4% (range, 3-6%) of the total carbamazepine binding regions in the AGP column. Possible sources of this binding site heterogeneity were considered. It was found that these two ligand populations were most likely a property of the original AGP preparation rather than a result of the immobilization process. ^ The last part focused on the development and characterization of a new immobilization method for HPAC. The amount of protein that can
digitalcommons.unl.edu/dissertations/AAI3216417/
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