Alpha-chymotrypsin
Chymotrypsin (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. It is activated in the presence of trypsin. The hydrophobic and shape complementarity between the peptide substrate P1 sidechain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine and methionine at the P1 position.
Structurally, it is the archetypal structure for its superfamily, the PA clan of proteases.

This is an excerpt from the article Alpha-chymotrypsin from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article Alpha-chymotrypsin at en.wikipedia.org was accessed 22 times in the last 30 days. (as of: 04/29/2014)
Images on Alpha-chymotrypsin
Preview image:
Original:
Search results from Google and Bing
1
1
1
Chymotrypsin - Wikipedia, the free encyclopedia
Chymotrypsin (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, ...
en.wikipedia.org/wiki/Chymotrypsin
2
>30
2
CHYMOTRYPSIN: Uses, Side Effects, Interactions and Warnings ...
A-Chymotrypsin, A-Chymotrypsine, Alpha-chymotrypsin, Alpha-chymotrypsine, Chymotrypsin A, Chymotrypsine A, Chymotrypsin B, Chymotrypsine B, ...
www.webmd.com/vitamins-supplements/ingredientmono-405-CHYMOTRYPSIN.aspx?activeIngredientId=405&activeIngredientName=CHYMOTRYPSIN
3
>30
3
Alpha-Chymotrypsin in Cataract Surgery
WATTS LF, Jr, MARTIN CJ. Stability of Alpha-chymotrypsin. Arch Ophthalmol. 1961 Jan;65:24–25. [PubMed]; THORPE HE. Enzymatic zonulolysis. Alpha ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC1848166/
4
>30
4
alpha-Chymotrypsin (C7762) - Product Information ... - Sigma-Aldrich
α-Chymotrypsin from bovine pancreas. Catalog Number C7762. Storage Temperature –20 °C. CAS RN 9004-07-3. EC 3.4.21.1. Product Description. Molecular ...
www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/c7762pis.pdf
5
>30
5
Chymotrypsin, alpha- - A to C | Sigma-Aldrich
Sigma-Aldrich Online Catalog Product List: Chymotrypsin, ...
www.sigmaaldrich.com/life-science/biochemicals/biochemical-products.html?TablePage=15821375
6
>30
6
Chymotrypsin, alpha - Substrates by Enzyme | Sigma-Aldrich
USA Home > Product Directory > Biochemicals and Reagents > Enzymes, Inhibitors, and Substrates > Enzyme Substrates > Substrates by Enzyme ...
www.sigmaaldrich.com/life-science/biochemicals/biochemical-products.html?TablePage=15844950
7
>30
7
α-Chymotrypsin from bovine pancreas Type II, lyophilized powder ...
Activation of alpha chymotrypsin by three phase partitioning is accompanied by aggregation. Rather GM, Mukherjee J, Halling PJ, et al. PLoS ONE 7(12), ...
www.sigmaaldrich.com/catalog/product/sigma/c4129?lang=en®ion=US
8
>30
8
alpha-Chymotrypsin
Catalog Number: 100461, 100465, 100468, 100475, 100478, 152272 Alpha-chymotrypsin CAS #: 9004-07-3 E.C. 3.4.21.1. Description: Chymotrypsin ...
www4.mpbio.com/ecom/docs/proddata.nsf/440121766f8ee75e8525645d0068b043/b20296eddf8b043b8525676d005e2b7f?OpenDocument
9
>30
9
AlphaChymotrypsin - Amoun Pharmaceutical Industries Company
AlphaChymotrypsin. Composition: Properties: - AlphaChymotrypsin® possesses potent anti-inflammatory properties that enable to hasten the resorption of ...
www.amoun.com/products-catalogue?page=shop.product_details&flypage=flypage.tpl&category_id=12&product_id=107
10
>30
10
Chymotrypsin Alfa (Catarase) Drug Information - Indications ...
Chymotrypsin Alfa(Catarase) generic is an anti-inflammatory enzyme, prescribed for abscesses, ulcers, surgery, or traumatic injuries and enzymatic zonulysis for ...
www.medindia.net/doctors/drug_information/chymotrypsin_alfa.htm
Search results for "Alpha-chymotrypsin"
Google: approx. 469.000
Alpha-chymotrypsin in science
Kinetics and mechanism of alpha-chymotrypsin catalyzed reactions.
University of Ottawa, Canada's University · uoZone · Library · Search ... Title: Kinetics and mechanism of Alpha-chymotrypsin catalyzed reactions. Author: Kaplan ...
Effects of molecular crowding by saccharides on α-chymotrypsin ...
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, ... In an effort to understand these differences, we have used α-chymotrypsin ...
[Alpha-chymotrypsin immobilized on ferromagnetic particles coated ...
Chemical Department, Moscow State University, Russia. Immobilization of Alpha-chymotrypsin on magnetic particles with stable coat with titanium oxides as a ...
Catalytic activity of the serine proteases alpha-chymotrypsin and ...
... 2nd, Kostić NM. Department of Chemistry, Iowa State University, Ames 50011. Incubation of Alpha-chymotrypsin and alpha-lytic protease with chloro(2,2':6' ...
Inhibition of alpha-chymotrypsin with an enzyme-activated n ...
Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA. Alpha-chymotrypsin was irreversibly inhibited with an enzyme-activated ...
Modelling pathways of alpha-chymotrypsin activation and deactivation.
The conformational change of Alpha-chymotrypsin from an inactive, chymotrypsinogen like structure at high pH to an .... Oxford Journals Oxford University Press.
chymotrypsin: Definition from Answers.com
Mechanism of peptide bond cleavage in α-chymotrypsin. Chymotrypsin .... Oxford Dictionary of Biochemistry Oxford University Press. Oxford Dictionary of ...
the action of alpha chymotrypsin upon mixtures of esters and ...
The Rockefeller University Press, doi: 10.1085/jgp.42.1.49 ... The behavior of α-chymotrypsin has been studied in the simultaneous presence of two different ...
Effect of Ionic Strength on the Kinetics of Trypsin and Alpha ...
The Rockefeller University Press, doi: 10.1085/jgp.44.6.1103. © 1961 Rockefeller ... Effect of Ionic Strength on the Kinetics of Trypsin and Alpha Chymotrypsin.
Refolding of urea-denatured α-chymotrypsin by protein-folding liquid ...
Oct 3, 2012 ... Refolding of urea-denatured α-chymotrypsin by protein-folding liquid chromatography. Ke Congyu1,*,; Sun Wujuan1,; Zhang Qunzheng1, ...
Development of Google searches


Blog posts on the term
Alpha-chymotrypsin
Erectile Dysfunction Evaluation: Alfaspin
What controllers are available on the WII for use with the Skylanders game? Alfaspin Buy alfaspin cheap. Dosage and uses.
erectile-dysfunction-evaluation.blogspot.com/2013/08/alfaspin.html
Adverse Effects for Bone Graft Material from Alpha-Chymotrypsin? | OsseoNews
Recently I heard a colleague talking about the effects of Alpha-chymotrypsin on the bone graft material and the membrane used to cover the graft.
www.osseonews.com/adverse-effects-for-bone-graft-material-from-alpha-chymotrypsin/
Alpha chymotrypsin 4, 2mg ~ Hướng dẫn bạn cách sử dụng thuốc đúng an toàn hiệu quả
Alpha chymotrypsin 4, 2mg  SĐK:VNA-3485-00 Dạng bào chế:Viên nén Đóng gói:Hộp 3 vỉ x 10 viên nén Giá kê khai: - Bán buôn:chờ cập nhật - Bán lẻ:chờ cập nhật Alpha chymotrypsin 4, 2mg  Nhà sản xuất:Công ty Dược & trang thiết bị Y tế Bình Định (BIDIPHAR) Nhóm Dược lý: Thuốc giảm đau, hạ sốt, Nhóm chống viêm không Steroid, Thuốc điều trị Gút và các bệnh xương khớp Thành phần:Alpha ChymotrypsineHàm lượng:4, 2mg+ Phần thông tin tham khảo - Dùng thuốc theo chỉ định của Bác sĩ + Chỉ định: - Điều trị các trường hợp phù nề do chấn thương, làm giảm & mất các bọc máu ở da. - Điều trị các trường hợp bong gân.
cachsudungthuoc.blogspot.com/2013/05/alpha-chymotrypsin-4-2mg.html
chymotrypsin: Alpha-Chymotrypsin: Webster's Timeline History, 1951 - 2007
Alpha-chymotrypsin: Webster's Timeline History, 1951 - 2007.
chymotrypsin.blogspot.com/2012/04/alpha-chymotrypsin-webster-timeline.html
Platelet interaction with collagen fibrils in flowing blood. I. Reaction of human platelets with alpha chymotrypsin-digested subendothelium | Protease,natural protease, protease products
The subendothelial surface rabbit aorta and Alpha-chymotrypsin digested subendothelium were exposed to anti-coagulated human blood in an annular flow pattern chamber. The wall shear rate was similar to that in large arteries (830 s-1) and exposure times of 2 1/2 to 40 min varies observed. The platelet reactive substrate of Alpha-chymotrypsin digested subendothelium consists of…
bioprotease.wordpress.com/2012/03/31/platelet-interaction-with-collagen-fibrils-in-flowing-blood-i-reaction-of-human-platelets-with-alpha-chymotrypsin-digested-subendothelium/
» Physiology MCQ – Thrombin inhibitor | PG Blazer
Which of the following inhibits thrombin activity? A. Heparin cofactor II B.
pgblazer.com/2013/08/physiology-mcq-thrombin-inhibitor.html
Reinvestigation of the phenacyl bromide modification of alpha-chymotrypsin - Glover, Mariano, Petersen, Reinvestigationphenacyl, bromide, modificationalpha-chymotrypsin - sciencestage.com Medicine
The modification of alpha-chymotrysin with phenacyl bromide has been reinvestigated over a wide pH range. Evidence is presented that indicates that the nature of the phenacyl-modified enzymes prepared by this reaction is dependent upon the pH of the reaction medium. The phenacyl Alpha-chymotrypsin produced at low pH is most probably the Met-192 phenacylsulfonium salt, as proposed earlier, since it readily undergoes dealkylation using 2-mercaptoethanol. However, the phenacyl-enzyme prepared at neutral pH possesses a much reduced enzymatic activity and does not react with 2-mercaptoethanol to regenerate native Alpha-chymotrypsin. In addition, incubation of the Met-192 phenacyl sulfonium enzyme at neutral pH causes a smooth irreversible change to the new phenacyl-enzyme as monitored by changes in enzymatic activity, susceptibility to dealkylation using 2-mercaptoethanol, and ultraviolet difference absorption spectral properties. The stoichiometries of both the low and neutral pH modification reactions have been determined, using [carbonyl-14C]phyena cyl bromide, to be 1 phenacyl group/enzyme molecule. In efforts to obtain information about the nature and mechanism of formation of the phenacyl Alpha-chymotrypsin produced at neutral pH, alkylation reactions of modified Alpha-chymotrypsins produced by His-57 functionalization with tosylphenylalanine chloromethyl ketone and by Met-192 oxidation to the sulfoxide have been investigated. The combined results of these studies have been initially interpreted in terms of a neutral pH, phenacyl bromide modification resulting in formation of a new modified enzyme via the Met-192 sulfonium salt....
sciencestage.com/d/9020/reinvestigation-of-the-phenacyl-bromide-modification-of-alpha-chymotrypsin.html
Biologically Active Fibronectin Fragments Stimulate Release of MCP-1 and Catabolic Cytokines from Murine Retinal Pigment Epithelium
www.iovs.org/content/50/6/2896.full
ILLUSTRATIVE EXAMPLES A. a-Chymotrypsin Part 1 (Enzyme Mechanisms)
Alpha-chymotrypsin (Fig. 2) catalyzes the facile hydrolysis of peptide bonds, in particular those adjacent to the carboxyl group of aromatic amino acids (tryptophan, ty-rosine, phenylalanine) as well as a variety of esters derived from similar N-acylated amino acids. The enzyme […]
what-when-how.com/enzyme-mechanisms/illustrative-examples-a-a-chymotrypsin-part-1-enzyme-mechanisms/
Megazyme Forte Plus (200 tablets) by Health Genesis
Scientifically engineered with an extensive blend of essential plant and proteolytic enzymes, including a high dose (45mg) of Alpha-chymotrypsin plus Serrazimes and Nattozimes. This is a highly effective product that may greatly assist in the digestion of foods as well as certain immune functions, cardiovascular and and lymphatic health.
www.the-natural-choice.co.uk/Megazyme-Forte-Plus-200-Tablets.html
123