Cortisol equivalent
Glucocorticoids (GCs) are a class of steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. The name glucocorticoid (glucose + cortex + steroid) derives from its role in the regulation of the metabolism of glucose, its synthesis in the adrenal cortex, and its steroidal structure (see structure to the right). A less common synonym is glucocorticosteroid.
GCs are part of the feedback mechanism in the immune system that turns immune activity (inflammation) down. They are therefore used in medicine to treat diseases caused by an overactive immune system, such as allergies, asthma, autoimmune diseases, and sepsis. GCs have many diverse (pleiotropic) effects, including potentially harmful side effects, and as a result are rarely sold over the counter. They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. This includes mainly inhibitory effects on lymphocyte proliferation (treatment of lymphomas and leukemias) and mitigation of side effects of anticancer drugs.
GCs cause their effects by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression).
Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. In technical terms, "corticosteroid" refers to both glucocorticoids and mineralocorticoids (as both are mimics of hormones produced by the adrenal cortex), but is often used as a synonym for "glucocorticoid." Glucocorticoids are chiefly produced in the zona fasciculata of the adrenal cortex, whereas mineralocorticoids are synthesized in the zona glomerulosa.
Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is essential for life, and it regulates or supports a variety of important cardiovascular, metabolic, immunologic, and homeostatic functions. Various synthetic glucocorticoids are available; these are used either as replacement therapy in glucocorticoid deficiency or to suppress the immune system.

This is an excerpt from the article Cortisol equivalent from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article Cortisol equivalent at en.wikipedia.org was accessed 16 times in the last 30 days. (as of: 05/28/2014)
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Corticosteroids conversion calculator (hydrocortisone ... - GlobalRPh
Oct 15, 2013 ... Glucocorticoid, Approximate Equivalent dose (mg), Half-life (Biologic) hours. Short-Acting. Cortisone, 25, 8-12. Hydrocortisone, 20, 8-12.
www.globalrph.com/corticocalc.htm
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Adrenal Hormone Replacements - National Adrenal Diseases ...
Hydrocortisone, Half-Life. Equivalent Glucocorticoid Dose (mg), Anti- Inflammatory, Mineral- Corticoid, Plasma (minutes), Duration of Action (hours). Short Acting.
www.nadf.us/tools/adrenalhormone.htm
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Corticosteroids - LiverTox - National Institutes of Health
AGENT, GLUCOCORTICOID ACTIVITY, MINERALOCORTICOID ACTIVITY, EQUIVALENT ORAL OR INTRAVENOUS DOSE. Cortisol, 1, 1, 20. Cortisone, 0.8  ...
livertox.nih.gov/Corticosteroids.htm
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The effects of adrenocorticotrophic hormone and an equivalent dose ...
The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol ... another group was treated with cortisol 150 mg ID (50 mg tid) daily for 4 days, ...
www.ncbi.nlm.nih.gov/pubmed/16839845
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MedCalc: Steroid Equivalence Converter
Oct 1, 1999 ... Steroid Equivalence Converter ... Relative Potency is relative to hydrocortisone. DISCLAIMER: All calculations must be confirmed before use.
www.medcalc.com/steroid.html
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Prednisone Dosage - Buzzle
Feb 6, 2013 ... This drug is 4-5 times more potent than cortisol. 5 mg or prednisone is equivalent to the amount of cortisol produced by the body in one day.
www.buzzle.com/articles/prednisone-dosage.html
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prednisolone to hydrocortisone equivalence - General Practice ...
Equivalent anti-inflammatory doses of different oral corticosteroids. This table takes no account of mineralocorticoid effects, nor does it take account of variations ...
www.gpnotebook.co.uk/simplepage.cfm?ID=x20061130195624295600
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Conventional RIA underestimates cortisol suppression in the ...
Extrapolating between these two values, it seems that 1 mg per day inhaled fluticasone produces equivalent serum cortisol suppression to 7.9 mg per day oral ...
thorax.bmj.com/content/57/9/837.2.full
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Glucocorticoids Are Orthomolecular Hormones (Nov 2012 ...
The unstressed human body makes about 35 mg of cortisol (the equivalent of 7 mg of prednisone) in the adrenal cortex every day. Prescriptions that exceed ...
www.townsendletter.com/Nov2012/booksafeuse1112.html
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Glucocorticoid Replacement—How Much Is Enough?
Mar 1, 2006 ... More recent studies measure production at 5–7 mg/m2·d, which equates to a replacement dose of oral hydrocortisone equivalent to 10–12 ...
jcem.endojournals.org/content/91/3/793.full
Search results for "Cortisol equivalent"
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Cortisol equivalent in science
Steroid Conversion - Welcome to the University of Toronto core ...
University of Toronto, Department of Medicine ... Prednisone 5 mg is equivalent to: Cortisone-acetate ... Hydrocortisone (Solucortef) 20 mg. Methylprednisolone ...
Maternal Adrenocorticotropin, Cortisol and Thyroid Hormone ...
We previously reported that third trimester-equivalent only alcohol exposure in sheep .... Animal Care and Use Committee (IACUC) at Texas A&M University.
Hydrocortisone effect on hyaluronate synthesis in a self-assembled ...
Aug 16, 2013... Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA. Human dermal matrix is a 'self-assembled' dermal equivalent ... We sought to investigate the actions of the hormone hydrocortisone on ...
Corticosteroids conversion calculator (hydrocortisone ... - GlobalRPh
Oct 15, 2013 ... Glucocorticoid, Approximate Equivalent dose (mg), Half-life ... Hydrocortisone, 20 , 8-12 ... Oxford ; New York : Oxford University Press, 2005.
University of Washington Medicine Consult Service
*Steroid equivalents: 5 mg prednisone = 4mg methylprednisolone =0.75 mg dexamethasone = 20mg hydrocortisone. 2. Dosing Recommendations (based upon ...
[PDF]Human hair follicles display a functional equivalent - The FASEB ...
*Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan; ... synthesis of cortisol and regulatory feedback loops as.
Conventional RIA underestimates cortisol suppression in the ...
The recent letter from Meijer et al1concludes that measuring serum cortisol by RIA ... equivalent serum cortisol suppression to 7.9 mg per day oral prednisolone. .... Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 ...
[PDF]Continuous subcutaneous hydrocortisone infusion in Addison's ...
1Division of Endocrinology, Institute of Medicine, University of Bergen, and 2Department of Medicine, ... 20–30mg daily, equivalent to cortisone acetate (CA).
[PDF]The Effects of Cortisol on Emotion by Keith Daniel ... - Deep Blue
In The University of Michigan .... Chapter 2: Cortisol Administration and the Hemodynamic Response. ...... The synthetic equivalent of endogenous cortisol is.
Books on the term Cortisol equivalent
Principles and Practice of Endocrinology and Metabolism
Principles and Practice of Endocrinology and Metabolism
Kenneth L. Becker, 2001
Cortisone is used interchangeably with cortisol, with 25 mg of cortisone considered equivalent to 20 mg of cortisol. Usually, there is little to favor one compound over the other, except habit or price. However, in severe liver disease, cortisol is ...
The Harriet Lane Handbook: Mobile Medicine Series, Expert Consult: Online and Print, 19e
The Harriet Lane Handbook: Mobile Medicine Series, Expert Consult: Online and Print, 19e
2011
Trusted by generations of residents and practitioners, The Harriet Lane Handbook from The Johns Hopkins University remains your first choice for fast, accurate information on pediatric diagnosis and treatment. Now even more convenient to carry, it's your go-to resource for a wealth of practical information, including the latest treatment and m...
Pediatric Critical Care Medicine: Basic Science And Clinical ...
Pediatric Critical Care Medicine: Basic Science And Clinical ...
Derek S. Wheeler, Hector R. Wong, Thomas P. Shanley, 2007
When considering the dose of hydrocortisone to be used for patients with shock it is important to understand two concepts. First, hydrocortisone must be multiplied by 6 to be glucocorticoid equivalent to methylprednisolone and by 30 to be ...
The ICU Book, 3rd Edition
The ICU Book, 3rd Edition
2006
This best-selling resource provides a general overview and basic information for all adult intensive care units. The material is presented in a brief and quick-access format which allows for topic and exam review. It provides enough detailed and specific information to address most all questions and problems that arise in the ICU. Emphasis on funda...
Principles of Ambulatory Medicine
Principles of Ambulatory Medicine
Nicholas H. Fiebach, Lee Randol Barker, John Russell Burton, 2007
All are marketed as ester derivatives or salts of esters (e.g., cortisol sodium hemisuccinate [Solu-Cortef]). For practical purposes, only cortisol and cortisone have significant salt-retaining (mineralocorticoid) action. 'Also equivalent to daily  ...
Discovering Biological Psychology
Discovering Biological Psychology
2009
With its comprehensive, authoritative coverage and student-centered pedagogy, DISCOVERING BIOLOGICAL PSYCHOLOGY, 2nd Edition is ideal for a broad range of students taking a beginning undergraduate course in biological or physiological psychology. The book provides a foundational understanding of the structure and function of the nervous system and ...
Risk Assessment and Oral Diagnostics in Clinical Dentistry
Risk Assessment and Oral Diagnostics in Clinical Dentistry
Dena J. Fischer, Nathaniel S. Treister, Andres Pinto, 2012
table 5.3 Cortisol equivalent of corticosteroid medications. Medication Potency equivalent to cortisol (medication: cortisol) Medication dose (equivalent to 25 mg of cortisol*) Hydrocortisone 1:0.8 31.25 mg Prednisone/Prednisolone 1:4 6.25 mg  ...
Hypothyroidism Type 2: The Epidemic
Hypothyroidism Type 2: The Epidemic
2005
An astonishing book revealing the cause and successful treatment for the plague of illnesses affecting western civilization; including obesity, heart attacks, depression, diabetes, strokes, headaches, chronic fatigue, and many more. In Dr. Starr's description of Type 2 Hypothyroidism, he presents overwhelming evidence showing a majority of Ame...
Resuscitation and Stabilization of the Critically Ill Child
Resuscitation and Stabilization of the Critically Ill Child
Derek S. Wheeler, Hector R. Wong, Thomas P. Shanley, 2008
When considering the dose of hydrocortisone to be used for patients with shock it is important to understand two concepts. First, hydrocortisone must be multiplied by 6 to be glucocorticoid equivalent to methylprednisolone and by 30 to be ...
Principles of Ambulatory Medicine
Principles of Ambulatory Medicine
2006
Updated for its Seventh Edition, Principles of Ambulatory Medicine is the definitive reference for all clinicians caring for adult ambulatory patients. It provides in-depth coverage of the evaluation,management, and long-term course of all clinical problems addressed in the outpatient setting. A major focus is on preventive care, grounded in excell...
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Blog posts on the term
Cortisol equivalent
A patented alarm clock app for iPhone and Android reduces cortisol | Mac Fanatic
www.macfanatic.net/blog/2013/11/12/a-patented-alarm-clock-app-for-iphone-and-android-reduces-cortisol/
Physical Activity Moderates Effects of Stressor-Induced Rumination on Cortisol Reactivity
www.psychosomaticmedicine.org/content/73/7/604.abstract
10% Discount Cortisol Samples With Free Shipping; Secure Alternative Cortisol Normal
forum.frogcp.com/thread-49724.html
Regulated Cortisol Release Linked to Improved Stress | Psych Central News
Findings from a new study suggest that a steady, predictable release of cortisol in the body can improve stress. Also known as hydrocortisone, cortisol is
psychcentral.com/news/2010/09/01/regulated-cortisol-release-linked-to-improved-stress/
Apolipoprotein E Genotype, Cortisol, Linked to Cognition | Modern Medicine
APOE-ε4 genotype may play a role in an individual's susceptibility to the consequences of hypothalamic-pituitary-adrenal axis dysregulation on cognitive function, researchers report in a study published online July 1 in the American Journal of Psychiatry.
www.modernmedicine.com/modernmedicine/Family+Medicine/Apolipoprotein-E-Genotype-Cortisol-Linked-to-Cogni/ArticleNewsFeed/Article/detail/529057?contextCategoryId=40244&ref=25
Dairy Food Consumption and Meal-Induced Cortisol Response Interacted to Influence Weight Loss in Overweight Women Undergoing a 12-Week, Meal-Controlled, Weight Loss Intervention
jn.nutrition.org/content/143/1/46
Chronic Fatigue Syndrome, Low Cortisol & Cognitive Behavioral Therapy
Cognitive behavioral therapy (CBT) is frequently recommended for people with chronic fatigue syndrome (CFS or ME/CFS), but it's quite controversial. Some
chronicfatigue.about.com/b/2009/08/11/chronic-fatigue-syndrome-low-cortisol-cognitive-behavioral-therapy.htm
Solu Cortef (Hydrocortisone Sodium Succinate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions - Prescribing Information at RxList
Learn about the prescription medication Solu Cortef (Hydrocortisone Sodium Succinate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
www.rxlist.com/solu-cortef-drug.htm
Adrenal Fatigue is Bullshit and Doesn’t Exist | Troy's Thoughts on Sports
This is well documented -- I've been consuming monstrous amounts of caffeine since Saturday, March 28, 2009. From May 2009 throughout the summer 2009 (hell, it was actually until late October 2009), when I was up late every night until the sun would rise the following mornings, I was drinking four Monster Lo-Carbs a day…
tstos.wordpress.com/2013/11/10/adrenal-fatigue-is-bullshit-and-doesnt-exist/
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