Granulomatous disease, chronic
Chronic granulomatous disease (CGD) (also known as Bridges–Good syndrome, Chronic granulomatous disorder, and Quie syndrome) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly, the superoxide radical) used to kill certain ingested pathogens. This leads to the formation of granulomata in many organs. CGD affects about 1 in 200,000 people in the United States, with about 20 new cases diagnosed each year.
This condition was first discovered in 1950 in a series of 4 boys from Minnesota, and in 1957 was named "a fatal granulomatosus of childhood" in a publication describing their disease. The underlying cellular mechanism that causes chronic granulomatous disease was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the disease. In 1986, the x-linked form of CGD was the first disease for which positional cloning was used to identify the underlying genetic mutation.

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Chronic Granulomatous Disease - Diseases…
05.03.2013 · Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects phagocytes of the innate immune system and leads to recurrent or persistent ...
emedicine.medscape.com/article/1116022-overview
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Chronic Granulomatous Disease Symptoms, Diagnosis & Treatment
An overview of Chronic Granulomatous Disease (CGD) symptoms, diagnosis, treatment and management written and reviewed by the leading experts in allergy, ...
www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease/chronic-granulomatous-disease.aspx
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Chronic granulomatous disease — Diagnosis and treatment at Mayo ...
Chronic granulomatous disease Learn more about diagnosis and treatment at Mayo Clinic.
www.mayoclinic.org/chronic-granulomatous-disease/
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Chronic granulomatous disease - Wikipedia, the free encyclopedia
Chronic granulomatous disease (CGD) (also known as Bridges–Good syndrome, Chronic granulomatous disorder, and Quie syndrome) is a diverse group of ...
en.wikipedia.org/wiki/Chronic_granulomatous_disease
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Chronic granulomatous disease: MedlinePlus Medical Encyclopedia
Factsheet with causes, symptoms, examinations and tests, treatment, outlook and prevention.
www.nlm.nih.gov/medlineplus/ency/article/001239.htm
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CGD Society - Home
We are a charity based in the UK whose mission is to support individuals and families affected by chronic granulomatous disorder. We aim to be the world's ...
www.cgdsociety.org/
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OMIM Entry - # 306400 - GRANULOMATOUS DISEASE, CHRONIC ...
Chronic granulomatous disease is a genetically heterogeneous ... Chronic granulomatous disease can be caused by mutations in any 1 of 5 genes encoding ...
www.omim.org/306400
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Chronic Granulomatous Disease - National Primary ...
Chronic Granulomatous Disease occurs once in every one million persons. It is far more common in males than females by a ratio of 4 to 1. Approximately 80% ...
www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=syndromes&area=7
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Chronic Granulomatous Disease Association
Non-profit organization aiming to get people well and fund research. Includes information on the disorder and its treatment.
www.cgdassociation.org/
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Chronic Granulomatous Disease (CGD) - PIDTC - Rare Disease
Chronic Granulomatous Disease (CGD) is an inherited condition characterized by a defect of specific white blood cells called neutrophils. These cells are ...
rarediseasesnetwork.epi.usf.edu/pidtc/cgd/
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Granulomatous disease, chronic in science
Chronic granulomatous disease | University of Maryland Medical ...
Chronic granulomatous disease is an inherited disorder in which immune system cells called phagocytes do not function properly. This leads to ongoing and ...
[Clinical features of chronic granulomatous disease].
OBJECTIVE: Chronic granulomatous disease (CGD) is a rare primary ... diagnosed in Children's Hospital of Fudan University from January, 2004, to June , 2011.
Molecular diagnosis of X-linked chronic granulomatous disease in Iran
Chronic granulomatous disease (CGD) is an inherited disorder of pathogen killing by ... Children's Medical Center at Tehran University is the referral center for ...
Imaging of Chronic Granulomatous Disease in Children1
G.K., Department of Radiology, University of Iowa Hospitals and Clinics, 200 ... Chronic granulomatous disease (CGD) is a rare immunodeficiency disorder.
Pediatric Chronic Granulomatous Disease
Nov 12, 2012 ... Chronic granulomatous disease (CGD), an inherited disorder of phagocytic cells, results from an inability of phagocytes to produce bactericidal ...
Chronic Granulomatous Disease
Mar 5, 2013 ... Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects phagocytes of the innate immune system and leads to ...
Generalized Pain in a 20-Year-Old Man With Chronic ...
A 20-year-old man with chronic granulomatous disease presented at the University Hospital of Nantes (France) for the evaluation of a 3-week history of ...
AACI | Full text | Newly diagnosed chronic granulomatous disease in ...
Mar 6, 2013 ... Chronic Granulomatous Disease (CGD) is an inherited deficiency which ... 2 Division of Clinical Immunolgoy & Allergy, McMaster University, ...
Chronic Granulomatous Disease: The European Experience
Apr 21, 2009 ... Affiliation: 1st Department of Pediatrics, University of Athens, Aghia Sophia ... Chronic granulomatous disease (CGD) is an uncommon inherited ...
Granulomatous Disease, Chronic | University of Michigan Health ...
Jan 14, 2009 ... Important It is possible that the main title of the report Granulomatous disease, chronic is not the name you expected. Please check the ...
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Chronic Granulomatous Disease: New Insights for the Healthcare ...
Chronic Granulomatous Disease: New Insights for the Healthcare ...
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Chronic Granulomatous Disease: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Chronic Granulomatous Disease in a compact ...
National Institute of Allergy and Infectious Diseases, NIH: Volume ...
National Institute of Allergy and Infectious Diseases, NIH: Volume ...
Vassil St Georgiev, 2010
Ezekowitz, R. A., Orkin, S. H., and Newburger, P. E. (1987) Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous ...
Primary Immunodeficiency Diseases: Definition, Diagnosis, and ...
Primary Immunodeficiency Diseases: Definition, Diagnosis, and ...
Nima Rezaei, Luigi Notarangelo, Asghar Aghamohammadi, 2008
Lublin M, Bartlett DL, Danforth DN, Kauffman H, Gallin JI, Malech HL, Shawker T, Choyke P, Kleiner DE, Schwartzentruber DJ, Chang R, DeCarlo ES, Holland SM (2002) Hepatic abscess in patients with chronic granulomatous disease.
Hot Topics in Infection and Immunity in Children II: II
Hot Topics in Infection and Immunity in Children II: II
Andrew J. Pollard, Adam Finn, 2007
(2004). Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. J. lmmunol. 172. 636-643. olset. S.O. and Gallagher, J.T. (1990). Proteoglycans in haemopoietic cells. Biochim. Biophys. Ada 1032.
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Granulomatous disease, chronic
Variant of X-Linked Chronic Granulomatous Disease Revealed by a Severe Burkholderia cepacia Invasive Infection in an Infant
Case Reports in Immunology is a peer-reviewed, open access journal that publishes case reports in all areas of immunology.
www.hindawi.com/crim/immunology/2013/323614/
Defense against bacterial infection in chronic granulomatous disease | Science Codex
www.sciencecodex.com/defense_against_bacterial_infection_in_chronic_granulomatous_disease-116847
AACI | Full text | Newly diagnosed chronic granulomatous disease in a 44 year old male presenting with recurrent groin cellulitis and colitis
Chronic Granulomatous Disease (CGD) is an inherited deficiency which results from the absence or dysfunction of NADPH oxidase subunits in phagocytic cells. This condition is usually diagnosed in early childhood and presents with recurrent infections at epithelial surfaces such as the skin, lungs, and gut.
www.aacijournal.com/content/9/1/9
Fundus Findings in Chronic Granulomatous Disease | PcFr.net
pcfr.net/pc-mac-categories/pc-mac-gl-exclusive/fundus-findings-in-chronic-granulomatous-disease.html
Chronic Granulomatous Disease Life Expectancy | Share All Knowledge
Chronic Granulomatous Disease Symptoms  Chronic Granulomatous Disease Life Expectancy - Chronic granulomatous disease can be an inherited disease (inherited) disorder seen as a mikrobisid function of white blood cells are phagocytes (neutrophils, eosinophils. Monocytes.
muktie12.blogspot.com/2013/07/chronic-granulomatous-disease-life.html
Chronic Granulomatous Disease — NEJM
Images in Clinical Medicine from The New England Journal of Medicine — Chronic Granulomatous Disease
www.nejm.org/doi/full/10.1056/NEJMicm1106350
Medical Immunology | Full text | Chronic Granulomatous Disease; fundamental stages in our understanding of CGD
It has been 50 years since chronic granulomatous disease was first reported as a disease which fatally affected the ability of children to survive infections. Various milestone discoveries from the insufficient ability of patients' leucocytes to destroy microbial particles to the underlying genetic predispositions through which the disease is inherited have had important consequences. Longterm antibiotic prophylaxis has helped to fight infections associated with chronic granulomatous disease while the steady progress in bone marrow transplantation and the prospect of gene therapy are hailed as long awaited permanent treatment options. This review unearths the important findings by scientists that have led to our current understanding of the disease.
www.medimmunol.com/content/5/1/4
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease
jem.rupress.org/content/210/7/1403
Chronic Granulomatous Disease-Causes-Symptoms-Diagnosis-Treatment-Complications | Medindia
Chronic granulomatous disease is an inherited disorder in which immune system cells called phagocytes malfunction. It is also characterised by WBCs that cannot produce activated O2 compounds.
www.medindia.net/patients/patientinfo/chronic-granulomatous-disease.htm
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