Nucleic acid heteroduplexes
A heteroduplex is a double-stranded (duplex) molecule of nucleic acid originated through the genetic recombination of single complementary strands derived from different sources, such as from different homologous chromosomes or even from different organisms. One such example is the heteroduplex DNA strand formed in hybridization processes, usually for biochemistry-based phylogenetical analyses. Another example is the heteroduplexes formed when non-natural analogs of nucleic acids are used to bind with nucleic acids; these heteroduplexes result from performing antisense techniques using single-stranded peptide nucleic acid, 2'-O-methyl phosphorothioate or Morpholino oligos to bind with RNA.
In meiosis, the process of crossing-over occurs between non-sister chromatids, which results in new allelic combinations of a population. In crossing-over, a Spo11 enzyme makes staggered nicks in a pair of sister chromatid strands (in a tetrad organization of prophase). Subsequent enzymes trim back the 5' ends of the strand and a protein complex binds to the 3' single-stranded ends. Rad51 protein is recruited and binds in a protein complex to search for a complementary sequence analogous to double-strand-break repair. The filament searches for the homologous chromosome, strand invasion occurs where the new chromosome forms a D-loop over the bottom sister chromatid, then the ends are annealed. This process can yield double Holliday Junctions that when cut in a transversal pattern by endonucleases form 2 heteroduplex strand products.
Heteroduplex DNA is also a source of small RNAs (smRNAs), causing post-transcriptional gene silencing.

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Heteroduplex - Wikipedia, the free encyclopedia
A heteroduplex is a double-stranded (duplex) molecule of nucleic acid originated through the genetic recombination of single complementary strands derived ...
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Nucleic acid heteroduplexes - Medical Dictionary - The Free Dictionary
Definition of Nucleic acid heteroduplexes in the Medical Dictionary. Nucleic acid heteroduplexes explanation. Information about Nucleic acid heteroduplexes in ...
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Thermodynamics of DNA-RNA heteroduplex formation: effects of ...
Jan 3, 2008 ... Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand. Kaur H ...
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Nucleic Acid Heteroduplexes - MeSH Result
1: Nucleic acid heteroduplexes Double-stranded nucleic acid molecules (DNA- DNA or DNA-RNA) which contain regions of nucleotide mismatches ...
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Penn State Profiles | Nucleic Acid Heteroduplexes
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Nucleic Acid Heteroduplexes | Harvard Catalyst Profiles | Harvard ...
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these ...
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Nucleic Acid Heteroduplexes | UCSF Profiles
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these ...
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Patent US5795976 - Detection of nucleic acid heteroduplex ...
The present invention describes a method for separating heteroduplex and homoduplex DNA molecules in a mixture. In the method, such a mixture is applied to ...
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May 7, 2013 ... Nucleic acid heteroduplexes information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
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Nucleic acid heteroduplexes in science
Interresidue hydrogen bonding in a peptide nucleic acid.RNA ...
Interresidue hydrogen bonding in a peptide nucleic acid.RNA heteroduplex. R A Torres and T C Bruce. Department of Chemistry, University of California, Santa ...
A peptide nucleic acid (PNA) heteroduplex probe containing an ...
Mar 13, 2013 ... A peptide nucleic acid (PNA) heteroduplex probe containing an ... Institute of Advanced Energy, Kyoto University, Uji, Kyoto, 611-0011, Japan.
A Peptide Nucleic Acid (PNA) Heteroduplex Probe Containing an ...
Mar 13, 2013 ... A Peptide Nucleic Acid (PNA) Heteroduplex Probe Containing an Inosine– Cytosine Base Pair Discriminates a Single-Nucleotide Difference in ...
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Nucleic acid heteroduplexes: Double-stranded nucleic acid molecules ... Inc., 2 Department of Microbiology and Immunology, State University of New York at ...
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Department of Chemistry, University of California, Santa Barbara, CA 93106. Contributed by Thomas C. ... suggest that strands of peptide nucleic acids (PNAs) and ... strand in heteroduplex structures has been presented, the great stability of ...
The influence of locked nucleic acid residues on the thermodynamic ...
The influence of locked nucleic acid residues on the thermodynamic properties of 2′-O-methyl RNA/RNA heteroduplexes ... properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication ...
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Books on the term Nucleic acid heteroduplexes
Human Molecular Genetics Three
Human Molecular Genetics Three
Tom Strachan, Andrew P. Read, 2004
Any in situ hybridization reaction in which nucleic acids are labeled by attaching chemical groups which can fluoresce under certain wavelengths. Heteroduplex. A double-stranded DNA formed when two single-stranded sequences with partial  ...
Medical Biomethods Handbook
Medical Biomethods Handbook
John M. Walker, Ralph Rapley, 2005
Analysis of Heteroduplex DNA Heteroduplex DNA is formed by pairing an unknown nucleic acid strand with a reference strand of a known sequence. Single-stranded nucleic acids with complementary sequences come together and form a ...
PROG NUCLEIC ACID RES&MOLECULAR BIO
PROG NUCLEIC ACID RES&MOLECULAR BIO
Waldo E. Cohn, 1983
A more refined approach by heteroduplex analysis was then chosen to examine the divergent sequences within the ... Preliminary studies showed that WR-P\aLV DNA and the RHHV DNA formed a heteroduplex that suggests homology at ...
The Nucleic Acid Protocols Handbook
The Nucleic Acid Protocols Handbook
Ralph Rapley, 2000
Heteroduplexes are formed between wild-type and mutant DNA (or RNA) and reacted with hydroxylamine, which ... From: The Nucleic Acid Protocols Handbook Edited by: R. Rapley © Humana Press Inc., Totowa, NJ G A MA GCT Cr M WT ...
Molecular Biology of RNA Tumor Viruses
Molecular Biology of RNA Tumor Viruses
John Stephenson, 1980
Heteroduplex analysis is therefore an effective and informative method for identifying and mapping regions of major sequence nonhomology between related nucleic acid species. However, if a region of the heteroduplex is observed as duplex ...
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Nucleic acid heteroduplexes
Nucleic Acid: Heteroduplex Formation
DNA, is a nucleic acid (that contains the genetic instructions used in the development and functioning of all known living organisms
nucleicacid-rn.blogspot.com/2010/10/heteroduplex-formation.html
Nucleic Acid Analysis: Heteroduplex Formation
For mutation detection, the PCR product from a test sample is mixed with a homozygous reference PCR product in a 1:1 (v/v) ratio. The mixed DNA fragments are denatured at 95°C and then cooled slowly for reannealing of the DNA strands by gradually lowering the temperature at a rate of 1°C per 20 seconds from 95°C to 25°C.
nucleicacidanalysis.blogspot.com/2010/10/heteroduplex-formation.html
Heteroduplex (Molecular Biology)
Two single-stranded nucleic acid polymers with at least partial complementarity can form duplexes with stretches of double helix, corresponding to the regions of nucleotide sequence homology, interleaved with unpaired stretches, corresponding to noncomplementary regions. Two types of single-stranded loops are
what-when-how.com/molecular-biology/heteroduplex-molecular-biology/
Identification and recovery of minor HIV-1 variants using the heteroduplex tracking assay and biotinylated probes
nar.oxfordjournals.org/content/36/22/e146.abstract
Deoxyribonucleic Acid: Analysis of Heteroduplex DNA
DNA, is a nucleic acid (that contains the genetic instructions used in the development and functioning of all known living organisms
dn-acid.blogspot.com/2010/10/analysis-of-heteroduplex-dna.html
"Exploiting structural differences among heteroduplex molecules to simp" by Peter A. Zimmerman, Mary Carrington et al.
A novel approach to DNA probe hybridization and heteroduplex analysis, termed directed heteroduplex analysis (DHDA) is presented here to illustrate its utility in simplification of human lymphocyte antigen (HLA)- typing. By strategic labeling of single-stranded probe sequences, DHDA allows the identification of specific heteroduplex structures that contribute to the differentiation of DQAI and DQB1 alleles. Because of the high degree of polymorphism among major histocompatibility complex class 11 second exon sequences, this analysis of 50 different heteroduplex molecules provides evidence of the importance of unpaired bases and mismatched base pairs and their effect on heteroduplex electrophoretic-mobility differences. This strategy is further used to genotype accurately a family for DQAI which was previously analyzed by sequence specific oligonucleotide (SSO) probe hybridization. To differentiate by SSO-typing among the DQA1 and DQB1 alleles analyzed in this study requires the use of 23 different probes. Equivalent results are obtained by DHDA using only three probes. Therefore, this study suggests that accurate HLA-typing can be simplified by DHDA. Additionally, DHDA may be useful for differentiation of DNA sequence polymorphisms in other genetic systems.
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The Supreme Court's decision in the Myriad case has been almost universally hailed as being a great victory for patients, doctors, personalized medicine, and research. Precluding...
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L-Lysine hydrochloride(C6H15ClN2O2) is an essential free-form amino acid and is one of the 20 most common natural amino acids that the body needs for growt
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Within the replacement gradualist scenario, ribonucleotides were at the start replaced a few at a period and randomly in TNA sell old phones sequencesA less difficult Nucleic Acid.(alternative structures to DNA cell phone buyback and RNA) The nucleic acids, DNA and RNA, are the hereditary material which cells and germs use to generate steadfast...
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