PF4
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.

This is an excerpt from the article PF4 from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article PF4 at en.wikipedia.org was accessed 94 times in the last 30 days. (as of: 11/07/2013)
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HIT - Overview: Heparin-PF4 Antibody…
Evaluation of possible immune-mediated type II heparin-induced thrombocytopenia (HIT-II) which should be suspected for the following patients:
www.mayomedicallaboratories.com/test-catalog/Overview/81904
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HIT - Clinical: Heparin-PF4 Antibody…
Evaluation of possible immune-mediated type II heparin-induced thrombocytopenia (HIT-II) which should be suspected for the following patients:
www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/81904
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Haematologic Technologies - Platelet Factor 4 - PF4
Haematologic Technologies, Inc is a primary manufacturer of high-quality coagulation proteins and research reagents including platelet factor 4.
www.haemtech.com/Platelet_Proteins/PF4.htm
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Platelet factor 4 - Wikipedia, the free encyclopedia
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) .
en.wikipedia.org/wiki/Platelet_factor_4
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PF4 platelet factor 4 [Homo sapiens (human)]
5 days ago ... This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the ...
www.ncbi.nlm.nih.gov/gene/5196
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PF4 Gene - GeneCards | PLF4 Protein | PLF4 Antibody
Complete information for PF4 gene (protein-coding), platelet factor 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ...
www.genecards.org/cgi-bin/carddisp.pl?gene=PF4
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Pf4 MGI Mouse Gene Detail - MGI:1888711 - platelet factor 4
Homozygous and heterozygous null mice display increased platelet counts and reduced thrombus formation following vascular injury. Gene Ontology (GO)
www.informatics.jax.org/marker/MGI:1888711
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PF4 - Gene Symbol Report | HUGO Gene Nomenclature Committee
PF4. Approved Name info, platelet factor 4. HGNC ID info, HGNC:8861. Previous Symbols & Names info, "platelet factor 4". Synonyms info, "chemokine (C-X-C ...
www.genenames.org/data/hgnc_data.php?match=PF4
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PF4 (CXCL4) Human ELISA Kit (ab100628) | Abcam
PF4 (CXCL4) Human ELISA Kit ELISA kits datasheet (ab100628).
www.abcam.com/pf4-cxcl4-human-elisa-kit-ab100628.html
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Human PF-4 ELISA - RayBiotech
ELH-PF4-001-5PlateKit ($1,516.00). RayBio® Human PF-4 (CXCL4) ELISA Kit for serum, plasma, cell culture supernatants, and urine. Manual ELISA Overview.
www.raybiotech.com/human-platelet-factor-4-pf4-cxcl4-elisa-kit-for-serum-plasma-cell-culture-supernatant-and-urine.html
Search results for "PF4"
Google: approx. 1.740.000
PF4 in science
Mode of interaction between platelet factor 4 and heparin
Platelet factor 4 (PF4) is a platelet-derived protein capable of binding to, and thus neutralizing, the biological activities of heparin and ... Oxford University Press.
Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and ...
Dec 27, 2012 ... Affiliation: Beatson Institute for Cancer Research, University of Glasgow, Glasgow , ... Consequently, we demonstrate that PF4-Cre activity is not ...
[PDF]Pathogenic vs. non-pathogenic anti-PF4/heparin antibodies Distinct ...
Oct 4, 2013 ... Non-Pathogenic anti-Platelet Factor 4/Heparin Antibodies with ... Biology, University of Pennsylvania School of Medicine, 421 Curie Blvd., 1154 ...
Binding of heparin-dependent antibodies to PF4 modified by ...
Department of Hematology-Hemostasis, University Hospital of Tours GICC UMR ... Antibodies from all HIT samples bound to PF4/heparin in SPR assays with ...
Anti-PF4/heparin antibodies and venous graft occlusion in ...
Department of Pathology and Molecular Medicine, McMaster University, Hamilton , ... BACKGROUND: Anti-PF4/heparin antibodies are frequently generated after ...
Platelet factor 4 and Duffy antigen required for platelet killing of ...
Dec 7, 2012 ... Australian School of Advanced Medicine, Macquarie University, Sydney, ... Here, we show that the platelet molecule platelet factor 4 (PF4 or ...
CXCL4-platelet factor 4, heparin-induced thrombocytopenia and ...
Oslo University Hospital Rikshospitalet, Department of Haematology and Research ... Platelet factor 4 (CXCL4-PF4) is a chemokine that binds to and neutralizes ...
Heparin Platelet Factor 4 (HIT) Assay - UF PathLabs - University of ...
This assay is used in the diagnosis of the heparin-induced thrombocytopenia, which is an adverse drug reaction to heparin due to IgG antibodies to complexes  ...
[PDF]is the IgG- specific anti-PF4/heparin ELISA superior to ... - Hematology
1Department of Medicine, University of Pennsylvania, Philadelphia, PA; 2Departments of ... In addition to a polyspecific anti-PF4/heparin ELISA for the diagno-.
Cell Host and Microbe - Platelet Factor 4 Activity against P ...
Dec 13, 2012 ... Platelet Factor 4 Activity against P. falciparum and Its Translation to ... Department of Biochemistry and Molecular Biophysics, University of ...
Books on the term PF4
Thrombosis and Hemorrhage
Thrombosis and Hemorrhage
Joseph Loscalzo, Andrew I. Schafer, 2003
Functional assays of PF4 measure its ability to neutralize heparin or to induce nonenzymatic polymerization of fibrinogen. Anti- heparin activity may be measured using a modification of the heparin-thrombin clotting time in either a clot-based ...
The Adventures of Tintin, Vol. 4: Red Rackham's Treasure / The Seven Crystal Balls / Prisoners of the Sun (3...
The Adventures of Tintin, Vol. 4: Red Rackham's Treasure / The Seven Crystal Balls / Prisoners of the Sun (3...
2007
Volume 4 of the 3-in-1 Tintin series begins in the middle of an adventure, concluding the story begun in The Secret of the Unicorn. (Keeping all the two-part stories together was not possible in the 3-in-1 format because chronologically, the Unicorn/Rackham and Crystal/Prisoners two-parters are back to back.) Red Rackham's Treasure follows Tin...
Heparin-Induced Thrombocytopenia, Fourth Edition
Heparin-Induced Thrombocytopenia, Fourth Edition
Theodore E. Warkentin, Andreas Greinacher, 2007
PF4 tetramers complexed with platelet proteoglycan E.C. PF4-H Complexes FIGURE 1 (See color insert) Release of PF4 from platelets as a high molecular weight complex of eight tetramers with a proteoglycan dimer; PF4 binds to endothelial ...
Cardiopulmonary Bypass: Principles and Practice
Cardiopulmonary Bypass: Principles and Practice
Glenn P. Gravlee, 2008
Effect of injection of protamine sulfate or recom- binant PF4 (rPF4) on the number of circulating white blood cells (A) and platelets (B). Number of experiments in parentheses. *p < 0.01, significantly different from platelet count before heparin.
Heparin-Induced Thrombocytopenia
Heparin-Induced Thrombocytopenia
Theodore Warkentin, Andreas Greinacher, 2003
PF4, heparin-PF4-IgG binding to platelets is minimized, and platelet activation and thrombocytopenia do not develop. The importance of heparin-PF4 stoichiometry in HIT was demonstrated in a serotonin- release assay using platelets from a ...
The Book of PF: A No-Nonsense Guide to the OpenBSD Firewall
The Book of PF: A No-Nonsense Guide to the OpenBSD Firewall
Peter N.M. Hansteen, 2010
OpenBSD's stateful packet filter, PF, is the heart of the OpenBSD firewall and a necessity for any admin working in a BSD environment. With a little effort and this book, you'll gain the insight needed to unlock PF's full potential.This second edition of The Book of PF has been completely updated and revised. Based on Peter N.M. Hans...
Chemistry and Biology of Heparin and Heparan Sulfate
Chemistry and Biology of Heparin and Heparan Sulfate
Hari G. Garg, Robert J. Linhardt, Charles A. Hales, 2011
A. Platelet Factor 4/Heparin Interactions The antigen(s) recognized by HIT antibodies are not located on heparin, but rather on PF4 that are formed when PF4 binds to heparin or certain other polyanions (3). PF4 is a 70-amino acid ( 7780 Da), ...
A Murder of Crows: A Sir Robert Carey Mystery (Sir Robert Carey Series)
A Murder of Crows: A Sir Robert Carey Mystery (Sir Robert Carey Series)
P. F. Chisholm, 2010
Set in 1592, Chisholm's fifth Sir Robert Carey mystery (after 2000's A Plague of Angels) includes a couple of potentially interesting supporting characters, Christopher Marlowe and William Shakespeare, but the playwrights come across as mere caricatures. Not much more developed are the two leads—Carey, the son of Anne Boleyn's sister...
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Blog posts on the term
PF4
AC DELCO PF48 FILTER-OIL (PF4 Buy | Careful Spry Facile Liberal
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LORAC – Porefection Baked Perfecting Powder (Pf4 (Medium)) – Beauty | LORAC
December 5, 2013CategoryLORAC - Porefection Baked Perfecting Powder (PF4 (Medium)) - Beautysittakorn.
lorac-beauty.deal365shop.com/lorac-porefection-baked-perfecting-powder-pf4-medium-beauty/
Distinct Specificity and Single-molecule Kinetics Characterize the Interaction of Pathogenic and Non-pathogenic Antibodies against Platelet Factor 4-Heparin Complexes with Platelet Factor 4
www.jbc.org/content/288/46/33060.abstract
Thrombosis Journal | Full text | Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia
Heparin Induced Thrombocytopenia (HIT) is caused by antibodies that recognize platelet factor 4 (PF4) associated with polyanionic glycosaminoglycan drugs or displayed on vascular cell membranes. These antibodies are elicited by multimolecular complexes that can occur when heparin is administered in clinical settings associated with abundant PF4. Heparin binding alters native PF4 and elicits immune recognition and response. While the presence of heparin is integral to immunogenesis, the HIT antibody binding site is within PF4. Thus HIT antibodies develop and function to cause thrombocytopenia and/or thrombosis only in the presence of PF4. Future emphasis on understanding the biology, turnover and regulation of PF4 may lead to insights into the prevention and treatment of HIT.
www.thrombosisjournal.com/content/11/1/7
Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4
bloodjournal.hematologylibrary.org/content/122/2/272
Complex formation with nucleic acids and aptamers alters antigenic properties of platelet factor 4
bloodjournal.hematologylibrary.org/content/early/2013/05/14/blood-2013-01-478966
Dhs pf4
Hi Guys and Girls, wanted to ask you if somebody of you have some experience with the PF 4 from DHS.
www.tabletennisdaily.co.uk/forum/showthread.php?4539-Dhs-pf4
Critical Care | Full text | Anti-PF4/heparin antibodies associated with repeated hemofiltration-filter clotting: a retrospective study
Heparin-induced thrombocytopenia is an immune-mediated adverse drug reaction that is associated with a procoagulant state and both arterial and venous thrombosis. After observing two cases of repeated hemofiltration-filter clotting associated with high anti-PF4/heparin antibody concentrations, we systematically measured the anti-PF4/heparin antibody concentration in all cases of unexpected and repeated hemofiltration-filter clotting during continuous veno-venous hemofiltration (CVVH). The aim of this study was to identify factors associated with positive anti-PF4/heparin antibody in the case of repeated hemofiltration-filter clotting.
ccforum.com/content/12/3/r84
PF4 Rubber
I have been playing for a long time with this rubber at my back hand and I am a right handed player ampnbspFor many days i am not able to understand this ru
www.pingskills.com/table-tennis-forum/pf4-rubber/
See Through Clothes Clothing Experiments IR X-Ray See Through Vision
See Through Clothes Clothing Experiments X-Ray Vision
www.kaya-optics.com/products/experiments.shtml
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