Rapacuronium
Rapacuronium (Raplon) is a rapidly acting, non-depolarizing neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them.
Due to risk of fatal bronchospasm it was withdrawn from the United States market by Organon on March 27, 2001, less than 2 years after its FDA approval in 1999.

This is an excerpt from the article Rapacuronium from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article Rapacuronium at en.wikipedia.org was accessed 671 times in the last 30 days. (as of: 07/03/2014)
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Rapacuronium - Wikipedia, the free encyclopedia
Rapacuronium (Raplon) is a rapidly acting, non-depolarizing neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal ...
en.wikipedia.org/wiki/Rapacuronium
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Raplon (Rapacuronium) Drug Information: Description, User ... - RxList
Learn about the prescription medication Raplon (Rapacuronium), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
www.rxlist.com/raplon-drug.htm
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Raplon (Rapacuronium) Drug Information: Indications, Dosage and ...
Learn about indications, dosage and how it is supplied for the drug Raplon (Rapacuronium).
www.rxlist.com/raplon-drug/indications-dosage.htm
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A mechanism for rapacuronium-induced bronchospasm: M2 ...
Rapacuronium, which sought to fulfill these criteria, was withdrawn from clinical use due to a high incidence of bronchospasm resulting in death. Understanding ...
www.ncbi.nlm.nih.gov/pubmed/12657852
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Raplon (rapacuronium bromide) - Food and Drug Administration
Aug 16, 2013 ... Organon Inc. initiated a voluntary recall of Raplon® (Rapacuronium bromide) for injection.
www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm172580.htm
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Rapacuronium - University of Minnesota Medical Center, Fairview
Rapacuronium injection. What is Rapacuronium injection? Rapacuronium (Raplon®) is a muscle relaxant. It relaxes muscles in patients who are having ...
www.uofmmedicalcenter.org/healthlibrary/Article/2451
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DrugBank: Rapacuronium (DB04834)
Sep 11, 2007 ... Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. Structure, Thumb Download: MOL | SDF | SMILES | ...
www.drugbank.ca/drugs/DB04834
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Rapacuronium Side Effects in Detail - Drugs.com
Learn about the potential side effects of Rapacuronium. Includes common and rare side effects information for consumers and healthcare professionals.
www.drugs.com/sfx/rapacuronium-side-effects.html
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Rapacuronium (Raplon) Drug Information - Indications, Dosage ...
Rapacuronium(Raplon) generic is a neuromuscular blocker, prescribed as an adjunct to general anesthesia to facilitate tracheal intubations.
www.medindia.net/doctors/drug_information/rapacuronium.htm
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Onset/offset characteristics and intubating conditions of ... - BJA
We compared onset and offset of action and tracheal intubating conditions after Rapacuronium and rocuronium in 60 patients in a randomized, assessor-blinded  ...
bja.oxfordjournals.org/content/85/2/246.full.pdf
Search results for "Rapacuronium"
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Rapacuronium in science
Rapacuronium - University of Minnesota Medical Center, Fairview
Rapacuronium injection. What is Rapacuronium injection? Rapacuronium (Raplon®) is a muscle relaxant. It relaxes muscles in patients who are having ...
Pharmacokinetic analysis of rapacuronium and its metabolite during ...
The pharmacokinetics of Rapacuronium and its active metabolite, ORG 9488, were ... The institutional review board of Baylor University Medical Center approved ...
Rapacuronium recovery characteristics and infusion requirements ...
Keywords: neuromuscular block, Rapacuronium; anaesthetics, volatile, desflurane ; anaesthetics, volatile, sevoflurane; ... Oxford Journals Oxford University Press.
Rapacuronium 2.0 or 2.5 mg kg–1 for rapid‐sequence induction - BJA
As the non‐inferiority of intubating conditions after Rapacuronium 2.0 and 2.5 mg kg–1 could not be proven, .... Oxford Journals Oxford University Press. Site Map ...
Onset/offset characteristics and intubating conditions of ... - BJA
The onset time of Rapacuronium was shorter than rocuronium (87 (20) vs 141 (65) s, P
[PDF]Antagonism of rapacuronium using edrophonium or ... - BJA
1Department of Anaesthesia, University of Liverpool, Royal Liverpool University ... were given a single dose of Rapacuronium 1.5 mg kg–1 and the remainder ...
Women's Health Guide - University of Utah Health Care
Rapacuronium injection. What is Rapacuronium injection? Rapacuronium (Raplon®) is a muscle relaxant. It relaxes muscles in patients who are having ...
[PDF]Comparison of the Intubation Conditions Provided by Rapacuronium ...
Associate Professor, Department of Anesthesiology, University of t Professor ... fol and either 1.5 mg/kg Rapacuronium or 1.0 mg/kg succinyl- choline. The goal ...
Rapacuronium bromide - ScienceDirect
May 16, 2002 ... Rapacuronium bromide (Raplon; Organon Inc, West Orange, NJ) is a ... is an Assistant Chief Nurse Anesthetist at the University of Michigan ...
[PDF]Pharmacokinetics and Pharmacodynamics of Rapacuronium Bromide
1 Academic Department of Anaesthesia, University of Newcastle upon Tyne, .... Rapacuronium is an aminosteroidal nondepolarising neuromuscular blocking.
Books on the term Rapacuronium
Meyler's Side Effects of Drugs Used in Anesthesia
Meyler's Side Effects of Drugs Used in Anesthesia
Jeffrey K. Aronson, 2008
Rapacuronium. General. Information. Rapacuronium, an aminosteroid non- depolarizing neuromuscular blocking agent with a rapid onset and a comparatively short duration of action (1,2), was withdrawn from the US market in March 2001 ...
Clinical Anesthesia
Clinical Anesthesia
Paul G. Barash, Bruce F. Cullen, Robert K. Stoelting, 2012
Rapacuronium is metabolized to an active 17-OH derivative (ORG 9488) that has twice the neuromuscular blocking activity of the parent compound and is excreted slowly via the kidneys. Rapacuronium produced mild dose-related tachycardia ...
Emergency Pathophysiology: Clinical Applications for Prehospital Care
Emergency Pathophysiology: Clinical Applications for Prehospital Care
Samuel M. Galvagno, 2013
This succinct, problem-orientated text explains the pathophysiology of disease states commonly encountered by the pre-hospital care provider and gives detailed guidelines for using that knowledge to effectively manage the disease or disorder involved. The book, intended for providers of pre-hospital medical care at all levels of training, explains ...
Surgical Intensive Care Medicine
Surgical Intensive Care Medicine
John Merritt O'Donnell, Flávio Eduardo Nácul, 2009
Pipecuronium has been used to maintain patients paralyzed in the ICU.28 Rapacuronium Rapacuronium, an aminosteriod, nondepolarizing drug, is no longer available in the USA. As mentioned earlier, this drug had the potential to replace ...
Meyler's Side Effects of Drugs Used in Anesthesia
Meyler's Side Effects of Drugs Used in Anesthesia
Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon), 2008
Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician. A safe and efficient anesthesia practice requires appropriate drug knowledge. Catastrophes under anesthesia have focused a...
Textbook of Anaesthesia for Postgraduates
Textbook of Anaesthesia for Postgraduates
T. K. Agasti, 2010
Rapacuronium (ORG — 9487) Chemically Rapacuronium is a steroidal non depolarising muscle relaxant. Introduction of rocuronium in clinical practice stimulates the search for muscle relaxants which have rapid onset, but short duration of ...
Muskelrelaxanzien: Ein Kompendium (German Edition)
Muskelrelaxanzien: Ein Kompendium (German Edition)
Rafael Dudziak, 2001
Seit der Erwähnung von Curare kurz nach der ersten Reise von Kolumbus nach Amerika sind 450 Jahre, seit der ersten Anwendung des Muskelrelaxans Curare in der Anästhesie erst knapp 60 Jahre vergangen. Inzwischen ist der Gebrauch neuromuskulärer Blocker Routine geworden, ohne dass sich an der potentiellen Gefährlichkeit ihrer Wirkung etwas geändert h...
Rapacuronium
Rapacuronium
Lambert M Surhone, Mariam T Tennoe, Susan F Henssonow, 2011
This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate.
Litt's Pocketbook of Drug Eruptions and Interactions, Third Edition
Litt's Pocketbook of Drug Eruptions and Interactions, Third Edition
Jerome Z. Litt, MD, 2007
The only work of its kind, Litt's Pocketbook of Drug Eruptions and Interactions is formatted for quick reference in the doctor's office, on hospital rounds, and in consultations. New in the third edition is coverage of herbals and supplements, an expanded range of reaction patterns, and lists of potentially hazardous interactions. Coverin...
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Blog posts on the term
Rapacuronium
aa1504bw1498der503: Rapacuronium
Product Description High Quality Content by WIKIPEDIA articles! Rapacuronium (Raplon) is a rapidly acting, non-depolarizing neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them.
aa1504bw1498der503.blogspot.com/2012/01/rapacuronium.html
Skeletal Muscle Relaxants | howMed
Skeletal muscle relaxants are used in various surgical procedures during anesthesia, because they decrease spasm and spasticity. Classification Classified
howmed.net/pharmacology/skeletal-muscle-relaxants/
MedicoNotebook: Non Depolarizing Muscle Relaxants (NDMR)
Non Depolarizing Muscle Relaxants (NDMR) :No Muscle fassiculation. Slow onset and slow dissociation.
www.mediconotebook.com/2013/01/non-depolarizing-muscle-relaxants-ndmr.html
Determining the potency of neuromuscular blockers: are traditional methods flawed?
bja.oxfordjournals.org/content/early/2010/04/28/bja.aeq094
Dr.DV's PGMEE Notes: Skeletal Muscle Relaxants : Must Know's
Skeletal Muscle Relaxants : Always asked invaluable points1. Shortest acting SMR : Succinylcholine ( SCh)2.
pgmeenotesbydv.blogspot.com/2008/09/skeletal-muscle-relaxants-must-knows.html
Vancouver Go-Kart Spring GT | Bryan Clark
This Thursday at 11am PST will mark the beginning the the Spring GT race season in Vancouver. Mozilla Vancouver is set to take on a number of other local companies like Nitobi, mainsocial, KRANKY cafe, and others in several rounds of go-kart racing.
clarkbw.net/blog/2010/05/10/vancouver-go-kart-spring-gt/
Skeletal muscle relaxants | Master Of Medicine
This topic falls into one of the most confusing parts in pharmacology, the names,duration of action etc can be confusing. Some of the names we come across very often are: * Succinyl choline(Analogue of acetyl choline,acts on nicotinic Nm receptors) * Pancuronium * Rocuronium * Mivacurium * Atracurium These names are similar so learning and memorizing their properties can be a bit difficult.But finding some peculiarities in these names will help you. Succinyl choline Pancuronium(Steroidal) Atracurium(d-Tubocurarine group) Classification Skeletal muscle relaxants are classified into: 1. Centrally acting 2. Peripherally acting Peripherally acting again subdivided into: 1.Directly acting 2.Acting on neuromuscular junction Drugs acting on NMJ are again classified into: 1.Depolarizing 2.Non depolarizing Depolarizing:Succinyl choline 1. Also called suxamethonium 2. Only depolarizing skeletal muscle relaxant 3. Fastest onset of action 4. Shortest duration of action 5. Trigger malignant hyperthermia when used with halothane 6. Sch can stimulate autonomic ganglia 7. Cause hyperkalemia in patients with nerve and muscular disorders so CI in nerve disorders(Paraplegia,hemiplegia,GBS) and muscular disorders(muscular dystrophy,Myasthenia,crush injury,burns,rhabdomyolysis) 8. Increases all pressures so CI in glaucoma,head injury,increase BP, nausea and vomiting due to intragastric pressure. Non depolarizing 1. Steroidal 1. Pancuronium(Longest acting among the curonium group, have the longest SPANcuronium) 2. Rapacuronium(RAPIDcuronium,fastest acting but withdrawn from market) 3. Rocuronium(Replaced Rapacuronium and came to the front row as ROWcuronium,fastest acting non depolarizing in the market) 4. Vecuronium(For the Weakhearted, WEAKuronium better cardiovascular stability but CI in heptic disease and biliary obstruction. 5. Pipercuronium Benzylquinoline derivatives * Release histamine largest with d-TC and minimum with cis-atracurium * Block autonomic ganglia max with d-TC and metocurine. d-TC cause hypotension and broncho constriction. Doxacurium( DEXAcurium is longest acting and most potent SMR.) Mivacurium(Shortest acting non depolarizing SMR due to metabolism by esterase) Atracurium and cis atracurium metabolized by hoffman elimination and are DOC's in hepatic and renal insufficiency. Atracurium metabolized to laudanosine--->seizures 3.Gallamine- Least potent SMR,nephrotoxic and teratogenic Directly acting SMR Dantrolene and quinine Dantrolene inhibits release of Ca2+ from sarcoplasmic reticulum by inhibition of ryanodine receptors. DOC in malignant hyperthermia also useful in neuroleptic malignant syndrome. Adverse effects are hepatitis and muscle weakness Quinine can be used in nocturnal leg cramps. Centrally acting SMR They act on CNS and can cause sedation. Mephenesin group includes carisprodol,chlorzoxazone,chlormezanone,methocarbamol selectively inhibit polysynaptic reflexes. Benzodiazepines like diazepam and clonazepam inhibit both poly and monosynaptic reflexes.Useful in muscle spasms Baclofen is a GABAb agonist which increase K+ conductance thus inhibiting mono and polysynaptic reflexes.MS and spinal injuries Tizanidine is centrally acting alpha2 agonist with no effect on BP, used in MS,ALS and spinal injuries
masterofmedicine.com/skeletal-muscle-relaxants/
Respiratory Research | Full text | The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle
Dopamine signaling is mediated by Gs protein-coupled “D1-like” receptors (D1 and D5) and Gi-coupled “D2-like” receptors (D2-4). In asthmatic patients, inhaled dopamine induces bronchodilation. Although the Gi-coupled dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle (ASM) cells, the Gs-coupled dopamine D1-like receptor subtypes have never been identified on these cells. Activation of Gs-coupled receptors stimulates cyclic AMP (cAMP) production through the stimulation of adenylyl cyclase, which promotes ASM relaxation. We questioned whether the dopamine D1-like receptor is expressed on ASM, and modulates its function through Gs-coupling.
respiratory-research.com/content/14/1/89
List Of Banned Drugs By FDA | MediMoon
medimoon.com/2012/10/list-of-banned-drugs-by-fda/
Teka muna… | Ang Kontrobersyal na Buhay ni Jose
Matagal ko na ring inisip kung bakit tinawag na "Superman Returns".... Eh..san ba kasi s'ya galing?!?! Matapos kong suyurin ang internet...heto lamang ang nakalap kong mga kasagutan.... A) Pansamantala s'yang nawala dahil nag-aral s'yang mag ballet...?? B) Hmmm...dahil napadalas ang pagpunta nia sa mall para mag window shopping??? o C) ...Nagbakasakali s'yang maging…
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