TGF-B3
Transforming growth factor beta 3 (TGF-β3) is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.
TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin.

This is an excerpt from the article TGF-B3 from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article TGF-B3 at en.wikipedia.org was accessed 61 times in the last 30 days. (as of: 06/03/2014)
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TGF beta 3 - Wikipedia, the free encyclopedia
Transforming growth factor beta 3 is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs ...
en.wikipedia.org/wiki/TGF_beta_3
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Transforming growth factor, beta 3 - Wikipedia, the free encyclopedia
"Entrez Gene: TGFB3 transforming growth factor, beta 3". ^ De Crescenzo, Gregory; Pham Phuong L, Durocher Yves, O'Connor-McCourt Maureen D (May 2003) ...
en.wikipedia.org/wiki/Transforming_growth_factor,_beta_3
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TGFB3 transforming growth factor, beta 3 [Homo sapiens (human)]
Nov 8, 2013 ... This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell ...
www.ncbi.nlm.nih.gov/gene/7043
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TGFB3 Gene - GeneCards | TGFB3 Protein | TGFB3 Antibody
Complete information for TGFB3 gene (protein-coding), transforming growth factor, beta 3.
www.genecards.org/cgi-bin/carddisp.pl?gene=TGFB3
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TGF-beta 3 - R&D Systems - Products
Results 1 - 17 of 17 ... Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell ...
www.rndsystems.com/product_results.aspx?m=2157
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OMIM Entry - * 190230 - TRANSFORMING GROWTH FACTOR ...
(1992) isolated full-length cDNAs for TGFB3 from a human placenta cDNA library . The coding region encoded a protein of 849 amino acids with a single ...
www.omim.org/190230
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TGFB3 Recombinant Human Protein - Life Technologies
Recombinant Human Transforming Growth Factor β 3 (TGFB3) is a bioactive protein intended for use in cell culture applications. TGFB3 is involved in epithelial ...
www.lifetechnologies.com/order/catalog/product/PHG9302
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Tgfb3 - Mouse Genome Informatics - The Jackson Laboratory
Tgfb3 transforming growth factor, beta 3. MGI:98727 ...
www.informatics.jax.org/marker/MGI:98727
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Human TGF beta 3 Recombinant Protein Purified RUO - eBioscience
Human TGF beta 3 Recombinant Protein product details and ordering information.
www.ebioscience.com/human-tgf-beta-3-recombinant-protein.htm
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TGF-beta 3-E. coli human recombinant, expressed in E. coli, ≥98 ...
Sigma-Aldrich offers Sigma-SRP3171, TGF-beta 3-E. coli human for your research needs. Find product specific information including CAS, MSDS, protocols and ...
www.sigmaaldrich.com/catalog/product/sigma/srp3171?lang=en®ion=US
Search results for "TGF-B3"
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TGF-B3 in science
TGFB3 Gene - GeneCards | TGFB3 Protein | TGFB3 Antibody
Complete information for TGFB3 gene (protein-coding), transforming growth factor, ... UniProtKB, the University of Copenhagen DISEASES database, Novoseek, ...
OMIM Entry - * 190230 - TRANSFORMING GROWTH FACTOR ...
190230 - TRANSFORMING GROWTH FACTOR, BETA-3; TGFB3 - TGFB3. ... The C-terminal 112 amino acids of TGF-beta-3 share approximately 80% sequence identity .... in Man ® are registered trademarks of the Johns Hopkins University.
Tissue-specific expression of Cre recombinase from the Tgfb3 locus
Mice carrying the Alk5flox and Alk5ko alleles were obtained from S. Karlsson ( Lund University Hospital, Lund, Sweden). Tgfb3-Cre mice were generated as ...
The Effects of TGF-b3 Modulation on Scar Tissue Formation in the Pig
Of the three distinct subtypes of TGF-b present in humans, TGF-B3 has been ... MD, Department of Otolaryngology - Head and Neck Surgery, University of Texas  ...
Journal of Human Genetics - Abstract of article: TGFB3 displays ...
TGFB3 displays parent-of-origin effects among central Europeans with nonsyndromic cleft lip and ... 1Institute of Human Genetics, University of Bonn, Wilhelmstr.
Journal of Human Genetics - Abstract of article: PAX9 and TGFB3 ...
PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or ... Japan; 2Department of Human Genetics, Nagasaki University Graduate School of ...
JAX Mice Database - 002619 B6.129-Tgfb3/J
Strain data sheet for B6.129-Tgfb3 /J, JAX Mice stock number 002619. ... Strain, C57BL/6J. Donating Investigator, Thomas Doetschman, University of Arizona ...
JAX Mice Database - 012719 STOCK Tgfb3/J
In these Tgfb3-cre mice, expression of Cre recombinase is driven by the transforming growth ... Donating Investigator, Dr. Vesa Kaartinen, University of Michigan ...
Association of MSX1 and TGFB3 with Nonsyndromic Clefting - Cell
1 Department of Orthodontics, Ohio State University, Columbus ... Significant LD was found between CL/P and both MSX1 and TGFB3 and between CPO and ...
JCI - TGF-β inhibition enhances chemotherapy action against triple ...
Mar 1, 2013 ... (B) SUM159 and BT549 cells were treated with 2.5 ng/ml TGF-β1 with ..... retroviral vectors were provided by Yibin Kang (Princeton University, ...
Books on the term TGF-B3
Cleft Lip and Palate : From Origin to Treatment: From Origin ...
Cleft Lip and Palate : From Origin to Treatment: From Origin ...
Department of Medicine and Department Epidemiology Boston University School of Medicine and School of Public Health Diego F. Wyszynski Genetics Program, 2002
TGF-B Superfcrmily. The TGF-B superfamily of polypeptides performs a wide range of regulatory functions. Members include the TGF-B family (TGFB1, TGF- B2, TGF-B3, TGF-B4, and TGF-B5) and the more distantly related bone ...
Animal Models for the Study of Human Disease
Animal Models for the Study of Human Disease
2013
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences...
Pre-eclampsia: Etiology and Clinical Practice
Pre-eclampsia: Etiology and Clinical Practice
Fiona Lyall, Michael A. Belfort, 2007
TGF-bs act through receptors designated types I, II and III. TGF-b, produced primarily by the decidua, may regulate trophoblast invasion (Lala and Hamilton, 1996). Expression of TGF-B3 in placental villous tissue was reported to be low at 5À6 ...
Clinical Immunology: Principles and Practice (Expert Consult - Online and Print), 4e (Rich, Clinical Immunology...
Clinical Immunology: Principles and Practice (Expert Consult - Online and Print), 4e (Rich, Clinical Immunology...
2012
Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problem...
Mouse Models of Developmental Genetic Disease
Mouse Models of Developmental Genetic Disease
2011
Tgfb3 is expressed in the MEE as well as in the MES; thus, it is present just before and during PS fusion. Previous work revealed that Tgfb3 signaling acts both during the early and later steps of palatal fusion. Firstly, Tgfb3 mediates adhesion ...
Human Embryology and Developmental Biology: With STUDENT CONSULT Online Access, 4e
Human Embryology and Developmental Biology: With STUDENT CONSULT Online Access, 4e
2008
This thoroughly revised 4th edition offers both clear descriptions and explanations of human embryonic development based on all the most up-to-date scientific discoveries and understanding. Particular attention is paid to the fundamental aspects of molecular mechanisms in development, introducing you to major families of important developmental mol...
The Tumor Microenvironment
The Tumor Microenvironment
Rebecca G. Bagley, 2010
feedback loop through Smad6 expression, while TGF-b induces an inhibitory feedback loop through Smad7 expression, although BMPs and TGF-b can also induce Smad7 and Smad6 expression, respectively. Smad6 inhibits BMP and TGF-b ...
Principles of Regenerative Medicine, Second Edition
Principles of Regenerative Medicine, Second Edition
Robert Lanza, 2010
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advance...
Proteomics of Spermatogenesis
Proteomics of Spermatogenesis
G. S. Gupta, 2006
The TGF-B has dramatic effects on peritubular cell differentiation and the production of specific proteins. TGF-B3 mRNA expression peaked at an early pubertal stage, coincident with the initiation of spennatogenesis. Peritubular and Sertoli ...
Mesenchymal Stromal Cells: Biology and Clinical Applications (Stem Cell Biology and Regenerative Medicine)
Mesenchymal Stromal Cells: Biology and Clinical Applications (Stem Cell Biology and Regenerative Medicine)
2013
Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy...
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Blog posts on the term
TGF-B3
JCI - Blood pressure homeostasis is maintained by a P311–TGF-β axis
www.jci.org/articles/view/69884
Taking it Personally: One Father’s Genetic Quest | Tute Genomics News
September 23, 2013BlogReid Robison.
www.tutegenomics.com/news/taking-it-personally-one-fathers-genetic-quest/
Arthritis Research & Therapy | Full text | Constitutive upregulation of the TGF-b pathway in rheumatoid arthritis synovial fibroblasts
Genome-wide gene expression was comparatively investigated in early-passage rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFBs; n = 6 each) using oligonucleotide microarrays; mRNA/protein data were validated by quantitative PCR (qPCR) and western blotting and immunohistochemistry, respectively. Gene set enrichment analysis (GSEA) of the microarray data suggested constitutive upregulation of components of the transforming growth factor (TGF)-β pathway in RA SFBs, with 2 hits in the top 30 regulated pathways. The growth factor TGF-β1, its receptor TGFBR1, the TGF-β binding proteins LTBP1/2, the TGF-β-releasing thrombospondin 1 (THBS1), the negative effector SkiL, and the smad-associated molecule SARA were upregulated in RA SFBs compared to OA SFBs, whereas TGF-β2 was downregulated. Upregulation of TGF-β1 and THBS1 mRNA (both positively correlated with clinical markers of disease activity/severity) and downregulation of TGF-β2 mRNA in RA SFBs were confirmed by qPCR. TGFBR1 mRNA (only numerically upregulated in RA SFBs) and SkiL mRNA were not differentially expressed. At the protein level, TGF-β1 showed a slightly higher expression, and the signal-transducing TGFBR1 and the TGF-β-activating THBS1 a significantly higher expression in RA SFBs than in OA SFBs. Consistent with the upregulated TGF-β pathway in RA SFBs, stimulation with TGF-β1 resulted in a significantly enhanced expression of matrix-metalloproteinase (MMP)-11 mRNA and protein in RA SFBs, but not in OA SFBs. In conclusion, RA SFBs show broad, constitutive alterations of the TGF-β pathway. The abundance of TGF-β, in conjunction with an augmented mRNA and/or protein expression of TGF-β-releasing THBS1 and TGFBR1, suggests a pathogenetic role of TGF-β-induced effects on SFBs in RA, for example, the augmentation of MMP-mediated matrix degradation/remodeling.
arthritis-research.com/content/9/3/r59
Role of Integrin Switch and Transforming Growth Factor Beta 3 in Hypoxia-Induced Invasion Inhibition of Human Extravillous Trophoblast Cells
www.biolreprod.org/content/87/2/47.abstract
PLOS ONE: Signaling through the TGF Beta-Activin Receptors ALK4/5/7 Regulates Testis Formation and Male Germ Cell Development
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054606
Regenerating tissue to replace joints - News
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body.
www.virtualmedicalcentre.com/news/regenerating-tissue-to-replace-joints/15325
Study evaluates mechanisms of fractional CO2 laser on burn scars | Clínica Estética Dr. Escamilla
Study evaluates mechanisms of fractional CO2 laser on burn scars
blog.antonioescamilla.com/?p=59
PathoGenetics | Full text | Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant
Jeff is a dominant mouse mutant displaying chronic otitis media. The gene underlying Jeff is Fbxo11, a member of the large F-box family, which are specificity factors for the SCF E3 ubiquitin ligase complex. Jeff homozygotes die shortly after birth displaying a number of developmental abnormalities including cleft palate and eyes open at birth. TGF-β signalling is involved in a number of epithelial developmental processes and we have investigated the impact of the Jeff mutation on the expression of this pathway.
www.pathogeneticsjournal.com/content/2/1/5
JCI - TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
www.jci.org/articles/view/65416
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