Telenzepine
Telenzepine is a selective M1 antimuscarinic used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis; in neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active as the (–)-isomer at muscarinic receptors in the rat cerebal cortex.

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Telenzepine - Wikipedia, the free encyclopedia
Telenzepine is a selective M1 antimuscarinic used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic ...
en.wikipedia.org/wiki/Telenzepine
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Telenzepine dihydrochloride Supplier | CAS 147416-96-4 | Tocris ...
View and buy high purity Telenzepine dihydrochloride from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents.
www.tocris.com/dispprod.php?ItemId=2233
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Telenzepine dihydrochloride | CAS 147416-96-4 | Santa Cruz Biotech
Buy Telenzepine dihydrochloride (CAS 147416-96-4) a potent and selective muscarnic receptor antagonist from Santa Cruz. MF C19H22N4O2S.2HCl, MW ...
www.scbt.com/datasheet-204332-telenzepine-dihydrochloride.html
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Telenzepine is at least 25 times more potent than pirenzepine--a ...
Telenzepine is an analogue of pirenzepine with a higher potency and similar selectivity for M1-receptors in animals. In this placebo controlled, double blind, ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC1433086/
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Telenzepine is at least 25 times more potent than pirenzepine ... - Gut
SUMMARY Telenzepine is an analogue of pirenzepine witha higher potency and ... On a molar basis Telenzepine proved to be a 25 and 50 times more potent.
gut.bmj.com/content/28/7/888.full.pdf
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Telenzepine dihydrochloride hydrate solid, ≥98% (HPLC) | Sigma ...
Sigma-Aldrich offers Sigma-T122, Telenzepine dihydrochloride hydrate for your research needs. Find product specific information including CAS, MSDS, ...
www.sigmaaldrich.com/catalog/product/sigma/t122?lang=en®ion=US
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Telenzepine
Title: Telenzepine. CAS Registry Number: 80880-90-6. CAS Name: 4,9-Dihydro- 3-methyl-4-[(4-methyl-1-piperazinylacetyl)]-10H-thieno[3,4-b][1 ...
www.drugfuture.com/chemdata/telenzepine.html
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Effect of Telenzepine, an M1-Selective Muscarinic Receptor ...
Apr 24, 2002 ... Summary: Muscarinic M1-receptor antagonists can prevent the induction of a long-lasting excitatory post-synaptic potential in autonomic ...
www.sciencedirect.com/science/article/pii/S0952060084710106
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The muscarinic M1·receptor·selective antagonist, telenzepine, had ...
Telenzepine (3 mg orally at 6 p.m. for S days) in 21 patients with chronic obstructive pulmonary ... Telenzepine did not have a significant effect on forced ex-.
erj.ersjournals.com/content/6/3/378.full.pdf
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A homogeneous fluorescence polarization assay for the binding of ...
binding of CyDye labelled Telenzepine to CHO cells expressing M. 1 muscarinic acetylcholine receptors. Key words: Fluorescence polarization, receptor assay, ...
www.gelifesciences.com/gehcls_images/GELS/Related%20Content/Files/1314735988470/litdocCHOM1_FP_app_note_20110830222927.pdf
Search results for "Telenzepine"
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Telenzepine in science
[PDF]Telenzepine is at least 25 times more potent than pirenzepine ... - Gut
From the Chirurgische und Medizinische Kliniken Innenstadt, University ... SUMMARY Telenzepine is an analogue of pirenzepine witha higher potency and  ...
Telenzepine is at least 25 times more potent than pirenzepine--a ...
Chirurgische und Medizinische Kliniken Innenstadt, University of Munich, West ... Telenzepine is an analogue of pirenzepine with a higher potency and similar ...
Effects of telenzepine and L-364,718 on canine pancreatic secretion ...
Department of Medicine IV (Gastroenterology), University Hospital of Heidelberg at ... Before vagotomy, the higher doses of Telenzepine and of L-364,718 ...
Comparison of the effects of the M1-receptor antagonist telenzepine ...
Department of Medicine IV (Gastroenterology), University Hospital of ... Except for 20.25 nmol/kg/h Telenzepine, all tested doses of Telenzepine and/or ...
Influence of the M1-receptor antagonists telenzepine and ...
Department of Medicine, University of Essen, FRG. ... Both, Telenzepine and pirenzepine caused an overall significant inhibition of the cumulative incremental  ...
[PDF]ANTIMUSCARINIC ACTIVITY OF TELENZEPINE ON ... - ScienceDirect
tlnstitute of Pharmacology and 2Department of Urology, University of Parma, School ... The antimuscarinic activity of the selective Ml-blocking drug, Telenzepine, ...
[PDF]Molecular Probes for Muscarinic Receptors - American Chemical ...
The Telenzepine derivatives contain prosthetic ... tagonist Telenzepine (20) in a manner analogous to our ... 8 George Washington University Medical Center.
Telenzepine | Medical Research and Treatment Information from ...
Learn about Telenzepine treatment including its side effects, effectiveness, related symptoms, and alternatives based on 11 ... Telenzepine ... University of Ulm.
Intestinal permeation of nonquaternary amines: a study with ...
University of Illinois-Champaign ... Telenzepine and pirenzepine, two structurally similar compounds differing in lipid solubility, were administered either to the ...
[PDF]A homogeneous fluorescence polarization assay for the binding of ...
binding of CyDye labelled Telenzepine to CHO cells .... under licence from Carnegie Mellon University, US Patent Numbers 5,268,486 and 5,569,587 and Patent ...
Books on the term Telenzepine
Antacids and Anti Reflux Agents
Antacids and Anti Reflux Agents
Neena Washington, 1991
Telenzepine Telenzepine is a new pirenzepine analogue, with the tricyclic structure being modified and the side chain remaining unchanged. The anti- secretory potency of Telenzepine is 10 to 25 times that of pirenzepine; it has less ...
Acute Pancreatitis: Novel Concepts in Biology and Theraphy
Acute Pancreatitis: Novel Concepts in Biology and Theraphy
Markus Buchler, M. W. Buechler, Helmut Friess and Peter Malfertheiner, 1999
Still frightening to both patients and clinicians, acute pancreatitis is an acute inflammatory disease of the pancreatic gland that may lead to severe systemic response. Fortunately, the knowledge about this disease has increased considerably in the last two decades. On molecular and pathophysiologic bases, doctors do understand more clearly the pr...
Neurogastroenterology: From the Basics to the Clinics: Proceedings of the Falk Symposium No. 112 in Freiburg,...
Neurogastroenterology: From the Basics to the Clinics: Proceedings of the Falk Symposium No. 112 in Freiburg,...
H.-J. Krammer and M.V. Singer, 2000
In the last decade, some outstanding progress has been made in the field of neurogastroenterology, a term which has been introduced to account for the crucial role of the enteric, autonomic and central nervous system in the regulation of gastrointestinal functions in health and disease. These proceedings of Falk Symposium No. 112 on Neurogastroente...
Muscarinic Receptors in Airways Diseases
Muscarinic Receptors in Airways Diseases
Johan Zaagsma, Herman Meurs, Ad F. Roffel, 2001
Cazzola and colleagues [85] also studied the effect of 5 mg oral Telenzepine versus placebo and found 14% increase in FEV, and 26% of FEF50 versus baseline (time average over 6 h) in patients with COPD. The median of peak increase in ...
Muscarinic Receptors in Airways Diseases (Progress in Inflammation Research)
Muscarinic Receptors in Airways Diseases (Progress in Inflammation Research)
Johan Zaagsma, Herman Meurs and Ad F. Roffel, 2001
What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine rec...
Neurogastroenterology - From the Basics to the Clinics
Neurogastroenterology - From the Basics to the Clinics
H.-J. Krammer, M.V. Singer, 2000
caerulein dose, respectively (i.e. observed protein response to tryptophan or caerulein given together with secretin minus the response to secretin alone), were calculated to discriminate between the effects of Telenzepine on the response to ...
Foye's Principles of Medicinal Chemistry
Foye's Principles of Medicinal Chemistry
Thomas L. Lemke, David A. Williams, 2012
A number of compounds structurally related to pirenzepine have demonstrated a similar M1 selectivity; among these is Telenzepine (59). Because of their selectivity for muscarinic M1 receptors, pirenzepine and Telenzepine have been ...
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Blog posts on the term
Telenzepine
Anticholinergic drugs | howMed
Also known as muscarinic receptor antagonists. Muscarinic blockers block the muscarinic receptors. These include the naturally occurring alkaloids
howmed.net/pharmacology/anticholinergic-drugs/
Orphanet Journal of Rare Diseases | Full text | Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines
Many genetic diseases are due to defects in protein trafficking where the mutant protein is recognized by the quality control systems, retained in the endoplasmic reticulum (ER), and degraded by the proteasome. In many cases, the mutant protein retains function if it can be trafficked to its proper cellular location. We have identified structurally diverse correctors that restore the trafficking and function of the most common mutation causing cystic fibrosis, F508del-CFTR. Most of these correctors do not act directly as ligands of CFTR, but indirectly on other pathways to promote folding and correction. We hypothesize that these proteostasis regulators may also correct other protein trafficking diseases.
www.ojrd.com/content/8/1/11
Respiratory Research | Full text | Inhibition of granulocyte migration by tiotropium bromide
respiratory-research.com/content/12/1/24
Pretreating mice with RC or mg kg had | Epitope Tags/Tag Peptides Guide
www.pt141buy.com/?p=1028
Chiral What? Chiral How?. In the Pipeline:
pipeline.corante.com/archives/2010/12/15/chiral_what_chiral_how.php
Sequoia Enlightenment Labs: Galantamine: Advanced Neuroprotection
sequoiaenlightenmentlabs.blogspot.com/2013/01/galantamine.html
New Combination 665
The invention provides a pharmaceutical product comprising a first active ingredient which is N—[2-(Diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthyl)ethoxy]propanamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist;
www.freshpatents.com/New-combination-665-dt20081002ptan20080242649.php
Peptic Ulcer rest | Blogger Dream Man
Dr. Samir Matloub Acid peptic diseases include: gastroesophageal reflux disease (GERD), peptic ulcers (DU & GU) and stress related mucosal injury.
dream-man1.blogspot.com/2012/12/peptic-ulcer-rest.html
Autonomous nervous system | Dr Muna
Autonomous nervous system (ANS) is divided into sympathetic (adrenergic) and parasympathetic (cholinergic) divisions. Autonomous nervous system maintains
drmuna.com/autonomous-nervous-system/
Mọi sự việc đều cần có một nền tảng vững chắc
Anticholinergic : muscarinic antagonist M1 và M3 (pirenzepine and Telenzepine ) cũng có thể ức chế chế tiết HCl, nhưng do tác dụng phụ của chúng nên cũng rất ít khi sử dụng. Hay có những thuốc như dicyclomine cũng có tác dụng tương tư Antacids Antacids - hệ đệm: tác dụng trung hòa lượng acids dư thừa có trong dạ dày.
drnguyenquocvu.blogspot.com/2012/05/anticholinergic-muscarinic-antagonist.html
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