Thorazine
Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ; marketed in the United States as Thorazine and elsewhere as Largactil or Megaphen) is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties used to treat schizophrenia. First synthesized on December 11, 1950, chlorpromazine was the first drug developed with specific antipsychotic action, and would serve as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents. The introduction of chlorpromazine into clinical use has been described as the single greatest advance in psychiatric care, dramatically improving the prognosis of patients in psychiatric hospitals worldwide.
Chlorpromazine works on a variety of receptors in the central nervous system, producing potent anticholinergic,antidopaminergic, antihistaminic, and antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by this broad action: its anticholinergic properties cause constipation, sedation, andhypotension, and help relieve nausea. It also has anxiolytic (anxiety-relieving) properties. Its antidopaminergic properties can cause extrapyramidal symptoms such as akathisia (restlessness, aka the 'Thorazine shuffle' where the patient walks almost constantly, despite having nowhere to go due to mandatory confinement, and takes small, shuffling steps) and dystonia. It is known to cause tardive dyskinesia, which can be irreversible. In recent years, chlorpromazine has been largely superseded by the newer atypical antipsychotics, which are usually better tolerated, and its use is now restricted to fewer indications. In acute settings, it is often administered as a syrup, which has a faster onset of action than tablets, and can also be given by intramuscular injection. IV administration is very irritating and is not advised; its use is limited to severe hiccups, surgery, and tetanus.

This is an excerpt from the article Thorazine from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
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Thorazine (Chlorpromazine) Drug Information: Description, User ...
Jun 2, 2008 ... Learn about the prescription medication Thorazine (Chlorpromazine), drug uses, dosage, side effects, drug interactions, warnings, reviews and ...
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Chlorpromazine - Wikipedia, the free…
Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ ; marketed in the United States as Thorazine and elsewhere as Largactil or Megaphen) is a dopamine ...
en.wikipedia.org/wiki/Chlorpromazine
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Thorazine (chlorpromazine oral) medical facts from Drugs.com
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Thorazine - Mental Health Resource
Thorazine® is the brand name for chlorpromazine, one of the first-generation antipsychotic drugs. Developed in the early 1950s, Thorazine was originally used for ...
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Chlorpromazine: MedlinePlus Drug Information
Return to top. Promapar®¶; Thorazine®¶. ¶ This branded product is no longer on the market. Generic alternatives may be available. Last Revised - 05/16/2011.
www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html
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Thorazine in science
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Cambridge University Press logo ... Chlorpromazine. THERAPEUTICS. Brands. Thorazine; see index for additional brand names. Generic? Yes. Class.
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Jul 31, 2013 ... These findings are characteristic of long-term Thorazine use and are ... Ophthalmic Atlas Images by EyeRounds.org, The University of Iowa are ...
Chlorpromazine overdose | University of Maryland Medical Center
May 31, 2013 ... Chlorpromazine is a prescription medication used to treat psychotic disorders. It may also be used for other reasons, such as preventing ...
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Thorazine Beach
Thorazine Beach
Bradley Harris, 2013
Fiction. Mystery. Jack Minyard is a Private Dick down on his luck. He's badly overweight and on the wrong side of sixty. He's lost his marriage, and maybe a little of his mind too. After narrowly escaping charges in a statewide fraud and money laundering scandal, Jack has been working private contracts and counting on the kindness of stra...
Schizophrenia and Bipolar Disorders: Often Misdiagnosed, ...
Schizophrenia and Bipolar Disorders: Often Misdiagnosed, ...
Herbert Wagemaker, Ann Buchholz, 1996
When patients like Bill recover from the acute psychotic state, their dose of Thorazine can be cut back rapidly. In the acute phase of the illness, patients can end up on 1600 to 2000, even 2400, milligrams of Thorazine a day. When patients ...
Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America...
Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America...
Robert Whitaker, 2011
*Starred Review* When Whitaker (Mad in America, 2002) learned that between 1987 and 2007 the number of Americans disabled due to mental illness more than doubled despite a whopping $40 billion annual psychotropic drug tab, it gave him pause. Given their widespread use—greater than even that of cholesterol-lowering drugs—he had believed that psychop...
Concise Encyclopedia of Special Education: A Reference for ...
Concise Encyclopedia of Special Education: A Reference for ...
Cecil R. Reynolds, Elaine Fletcher-Janzen, 2004
However, Thorazine is still used as a benchmark against which new antipsychotic agents are compared in terms of frequency of side effects and efficacy. Thorazine is of the drug class phenothiazine and tends to produce the classic panorama ...
Crazy: A Father's Search Through America's Mental Health Madness
Crazy: A Father's Search Through America's Mental Health Madness
Pete Earley, 2007
It was marketed under the name Thorazine. Just as Deniker had promised, the results were staggering. Within a year, newsmagazines were calling Thorazine a “wonder drug” and reporters were claiming that a cure for most mental illnesses ...
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Thorazine
Thorazine – Wikipedia
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