Tsp protease
C-terminal processing peptidase (EC 3.4.21.102, CtpA gene product (Synechocystis sp.), photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme. This enzyme catalyses the following chemical reaction
The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II
Proteolytic processing of the D1 protein of photosystem II anables light-driven assembly of the tetranuclear manganese cluster.

This is an excerpt from the article Tsp protease from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
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Identification of Active Site Residues of…
Abstract. In a search for active-site residues of the Tsp protease, 20 positions were individually mutated to alanine, the mutant strains were assayed ...
www.jbc.org/content/270/48/28864.full
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Sequence Determinants of C-terminal…
Abstract. Cytochrome b is not cleaved by the tail-specific protease Tsp in vitro or in the periplasm of Escherichia coli but becomes a good substrate when the C ...
www.jbc.org/content/271/5/2589.full
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Tsp: A tail-specific protease that selectively degrades proteins with ...
(tail-specific protease) has been purified, and its gene has been cloned and ... Tsp shows no significant homology to known protease se- quences but does ...
www.pnas.org/content/89/1/295.full.pdf
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Escherichia coli K-12 substr. MG1655 tail-specific protease - BioCyc
Tail-specific protease (Tsp) is an ATP-independent periplasmic protease responsible for processing and degradation of a number of proteins [Park88a]. Specific ...
biocyc.org/ECOLI/NEW-IMAGE?type=ENZYME&object=EG10760-MONOMER
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Substrate Recognition through a PDZ Domain in Tail-Specific ...
ABSTRACT: Tail-specific protease (Tsp) is a periplasmic enzyme that selectively ... In this work, we show that substrate recognition of Tsp is mediated by a PDZ ...
www.andersonlab.com/articles/Chaudhury2000b.pdf
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Tail-specific protease precursor - Escherichia coli (strain K12)
Protein names, Recommended name: Tail-specific protease. EC= 3.4.21.102. Alternative name(s): C-terminal-processing peptidase. PRC protein. Protease Re.
www.uniprot.org/uniprot/P23865
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Tsp: a tail-specific protease that selectively degrades proteins with ...
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):295-9. Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini. Silber KR, Keiler KC, ...
www.ncbi.nlm.nih.gov/pubmed/1729701
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Degradation of carboxy-terminal-tagged cytoplasmic proteins by the ...
1990), so they are presumably recognized directly by proteolytic systems. The periplasmic protease Tsp (or Prc) specifically recognizes these tagged ...
genesdev.cshlp.org/content/12/9/1348.long
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Full Text - Journal of Bacteriology - American Society for Microbiology
Here, we report the characterization of CT441 as a tail-specific protease. CT441 contains a PDZ domain of protein-protein interactions and a Ser/Lys dyad ...
jb.asm.org/content/189/18/6619.full
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Substrate Specificity, Active-Site Residues, and Function of the Tsp ...
and Function of the Tsp protease by. Kenneth Charles Keiler. Submitted to the Department of Biology in partial fulfillment of the requirements for the degree of ...
www.researchgate.net/publication/38000102_Substrate_specificity_active-site_residues_and_function_of_the_Tsp_protease/file/d912f507ef17a932db.pdf
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Tsp protease in science
Substrate recognition through a PDZ domain in tail-specific protease.
Mar 21, 2000... The Ohio State University, 100 West 18th Avenue, Columbus, Ohio ... Tail-specific protease (Tsp) is a periplasmic enzyme that selectively ...
Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific ...
Here, we report the characterization of CT441 as a tail-specific protease. ... Zhong of the University of Texas Health Science Center at San Antonio, respectively, ...
[PDF]Substrate Specificity, Active-Site Residues, and Function of the Tsp ...
Function of the Tsp protease by. Kenneth Charles Keiler. B.S., Chemistry and Biology. Stanford University. June, 1989. M.S., Biology. Stanford University. June  ...
[PDF]Substrate Recognition through a PDZ Domain in Tail-Specific ...
ABSTRACT: Tail-specific protease (Tsp) is a periplasmic enzyme that selectively degrades .... Chemistry, The Ohio State University, 100 West 18th Avenue,.
Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific ...
Here, we report the characterization of CT441 as a tail-specific protease. CT441 contains a PDZ domain of protein-protein interactions and a Ser/Lys dyad ...
PDZ Domains Facilitate Binding of High Temperature Requirement ...
Oct 18, 2002 ... PDZ Domains Facilitate Binding of High Temperature Requirement Protease A ( HtrA) and Tail-specific Protease (Tsp) to Heterologous ...
[PDF]PDF(1503K) - Wiley Online Library
Cambridge University Press. ... Tsp is a periplasmic protease of Escherichia coli that was pu- ... Silber et al., 1992), and Tsp may be identical with protease Re.
[PDF]Interaction of the Escherichia coli Lipoprotein NlpI with Periplasmic ...
University, Miyama 2-2-1, Funabashi, Chiba, 274-8510; and 3Link Genomics, Inc. , Nihonbashi-Honcho 2-7-1, ... It is also known as Tsp protease because it.
Interaction of the Escherichia coli Lipoprotein NlpI with Periplasmic ...
... NlpI did not. Thus, it was suggested that NlpI was activated by Prc protease processing. ... Biochemical Society. Oxford Journals Oxford University Press.
Books on the term Tsp protease
Springer Handbook of Enzymes
Springer Handbook of Enzymes
Dietmar Schomburg, Ida Schomburg, Antje Chang, 2002
[1] Keiler, K.C.; Sauer, R.T.: Tsp protease. Handbook of Proteolytic Enzymes ( Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. eds.), 460-461 (1998) [2] Beebe, K.D. ; Shin, J.N.; Peng, J.; Chaudhury, C.; Khera, J.; Pei, D.H.: Substrate recognition ...
Therapeutic Monoclonal Antibodies: From Bench to Clinic
Therapeutic Monoclonal Antibodies: From Bench to Clinic
2009
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety.Most chapters contain experimental data to illustrate th...
Sensory Mechanisms in Bacteria: Molecular Aspects of Signal ...
Sensory Mechanisms in Bacteria: Molecular Aspects of Signal ...
Stephen Spiro, Ray Dixon, 2010
Therefore it was proposed that autoproteolysis might be an important regulatory mechanism for protease activation. ... PDZ domains of Tsp, another PDZ protease : a sensor for destabilizing C-termini Tsp was initially identified based on its ...
Topics in Dental Biochemistry
Topics in Dental Biochemistry
2011
Over the last 20 years, biochemistry and molecular biology have undergone a revolution that has affected our understanding of the oral cavity. Topics in Dental Biochemistry is primarily designed for students of dentistry who need to relate biochemistry and molecular biology to dentally related topics in physiology, nutrition, anatomy, histology, mi...
Thrombospondin
Thrombospondin
Judith Lahav, 1993
In fact, it has been suggested on more than one occasion that proteolytic fragments of TSP released by certain proteases at specific sites may play important roles in some of the biological activities of this interesting family of proteins. When cut ...
RNA Turnover in Prokaryotes, Archae and Organelles (Methods in Enzymology, Vol. 447)
RNA Turnover in Prokaryotes, Archae and Organelles (Methods in Enzymology, Vol. 447)
2009
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing ...
Co- and Posttranslational Proteolysis of Proteins
Co- and Posttranslational Proteolysis of Proteins
2001
Independently, the Tsp (tail-specific protease) protein was purified from E. coli extracts using an assay for specific degradation of a variant of the N-terminal domain of A repressor containing hydrophobic residues at its five C-terminal positions ...
Osteoimmunology: Interactions of the Immune and Skeletal Systems
Osteoimmunology: Interactions of the Immune and Skeletal Systems
2010
Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This...
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Blog posts on the term
Tsp protease
Tail-specific protease precursor - Escherichia coli (strain K12)
www.uniprot.org/uniprot/P23865
Interaction of the Escherichia coli lipoprotein Nl... [J Biochem. 2004] - PubMed - NCBI
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
www.ncbi.nlm.nih.gov/pubmed/15047720
BMC Biotechnology | Full text | A novel carboxyl-terminal protease derived from Paenibacillus lautus CHN26 exhibiting high activities at multiple sites of substrates
Carboxyl-terminal protease (CtpA) plays essential functions in posttranslational protein processing in prokaryotic and eukaryotic cells. To date, only a few bacterial ctpA genes have been characterized. Here we cloned and characterized a novel CtpA. The encoding gene, ctpAp (ctpA of Paenibacillus lautus), was derived from P. lautus CHN26, a Gram-positive bacterium isolated by functional screening. Recombinant protein was obtained from protein over-expression in Escherichia coli and the biochemical properties of the enzyme were investigated.
www.biomedcentral.com/1472-6750/13/89
A continuous fluorimetric assay for tail-specific protease. - Abstract - Europe PubMed Central
Author: Beebe KD, Journal: Analytical biochemistry[1998/10], Abstract: A continuous fluorimetric assay for tail-specific protease (Tsp) has been developed using a fluorescence donor/quencher system, in which 5-[(2-aminoethyl) amino]naphthalene-1-sulfonic acid...
europepmc.org/abstract/MED/9750142
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
www.pnas.org/content/105/22/7702.long
Digest This! Blog Serratiopeptidase Enzyme by Dr. M. Mamadou
www.enzymedica.com/community/digest-this-blog/post/serratiopeptidase-enzyme-by-dr-m-mamadou.html
Which Fruits Can Ruin Your Gelatin Dessert?
Fruit and gelatin science project: Determine if the enzymes in some fruits prevent gelatin from solidifying and if heating these fruits can stop the activity of their enzymes.
www.sciencebuddies.org/science-fair-projects/project_ideas/FoodSci_p004.shtml
Savory Seasonings: Herb Breadsticks
Herb Breadstickshttp://savoryseasonings.blogspot.com/4 ½ tsp. active dry yeast2 ¼ cup warm water4 ½ tsp.
savoryseasonings.blogspot.com/2010/11/herb-breadsticks.html
Frontiers | Chlamydia Trachomatis Secretion of Proteases for Manipulating Host Signaling Pathways | Cellular and Infection Microbiology - closed section
The human pathogen C. trachomatis secretes numerous effectors into host cells in order to successfully establish and complete the intracellular growth cycle. Three C. trachomatis proteases (CPAF, T...
journal.frontiersin.org/Journal/10.3389/fmicb.2011.00014/full
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