Xylazine
Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico.
As with other α2 agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. Yohimbine (Yobine), tolazoline (commercial name Tolazine), and atipamezole (commercial name Antisedan) can be used to reverse xylazine effects. In veterinary anesthesia, xylazine is often used in combination with ketamine. No formal information in humans is available. Xylazine is sold by Bayer under the brand name Rompun.
Xylazine is also used to shorten the effects of musth on male elephants in Asia.

This is an excerpt from the article Xylazine from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article Xylazine at en.wikipedia.org was accessed 4,712 times in the last 30 days. (as of: 11/18/2013)
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Xylazine - Wikipedia, the free encyclopedia
Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia ...
en.wikipedia.org/wiki/Xylazine
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Xylazine HCl Injection for Animal Use - Drugs.com
Learn about Xylazine HCl Injection for animal usage including: active ingredients, directions for use, precautions, and storage information.
www.drugs.com/vet/xylazine-hcl-injection.html
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Xylazine - Drugs.com
Xylazine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Xylazine is available on the Drugs.com website.
www.drugs.com/international/xylazine.html
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Xylazine Horse Tranquilizer: The Next Zombie Drug? | The Fix
Jan 8, 2013 ... Xylazine is meant to help horses endure castration. An expert tells The Fix of the deadly risks of human use.
www.thefix.com/content/xylazine-horse-tranquilizer91115
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Rompun™ (xylazine) 100 mg/mL Injectable - BayerDVM
Rompun™ (Xylazine) can be used in horses when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia.
www.bayerdvm.com/show.aspx/rompun-xylazine-100-mgml-injectable
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Ketamine hydrochloride/xylazine hydrochloride solution ...
Sigma-Aldrich offers Sigma-K113, Ketamine hydrochloride/Xylazine hydrochloride solution for your research needs. Find product specific information ...
www.sigmaaldrich.com/catalog/product/sigma/k113?lang=en®ion=US
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The emerging of xylazine as a new drug of abuse and its health ...
The aim of this study was to document the use of "anestecia de caballo" (Xylazine ) and its consequences among drug users in Puerto Rico. The study combined ...
www.ncbi.nlm.nih.gov/pubmed/22391983
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Erowid Experience Vaults: Xylazine - Sedatives Are Just That ...
Jul 15, 2013 ... Being an insomniac, I took up the chance to experiment with tranquilizers when my dealer gave me the remnants of a bottle of Xylazine he had ...
www.erowid.org/experiences/exp.php?ID=24942
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XylaMed Xylazine HCl Injection Bimeda ( - Equine Pharmacy (Rx ...
Xylazine is a sedative and analgesic as well as a muscle relaxant. Xylazine HCl Injection is used in horses to produce a state of sedation accompanied by a ...
www.valleyvet.com/ct_detail.html?pgguid=07ee8074-d07c-47c2-a4b4-710f4eab3f18
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Xylazine HCI - wildlife pharmaceuticals usa
Description: Xylazine is used as a sedative and analgesic in Cervidae and other species of wildlife when it is desirable to produce a reversible state of sedation ...
wildpharm.com/xylazine-hydrochloride-300mgml.html
Search results for "Xylazine"
Google: approx. 658.000
Xylazine in science
IACUC Guidelines: Anesthesia | Office of Animal Resources ...
Oct 15, 2014 ... *Ketamine/Xylazine without combination with an analgesic agent (opioid ... Please contact a University of Iowa clinical veterinarian (link sends ...
Xylazine - ResearchGate
Why do we use ketamine and Xylazine in combination ? i need 15 ... Jorge Alonso Lopez Carrasco · Autonomous University of Baja California. I used also the ...
Mouse Formulary » Research Committees » Boston University
Higher ketamine dose with lower Xylazine dose are used for less invasive procedures and for very young/very old or critical patients. In general, higher doses of ...
Rat Formulary » Research Committees » Boston University
Higher ketamine dose with lower Xylazine dose are used for less invasive procedures and for very young/very old or critical patients. In general, higher doses of ...
Effect of a Short-term Fast on Ketamine–Xylazine Anesthesia in Rats
Although ketamine–Xylazine (KX) anesthesia is commonly used in rats, it is often ... and were included in a protocol approved by the University of Florida IACUC.
Toxic effects of xylazine on endothelial cells in combination with ...
Jul 8, 2014 ... Silva-Torres LA(1), Vélez C(2), Lyvia Alvarez J(3), Ortiz JG(4), Zayas B(5). Author information: (1)University of Puerto Rico, Pharmacology and ...
Veterinary Formulary - Health Sciences - University of Minnesota
Xylazine: can-0.6-2 mg/kg IM, IV, por-2-4 mg/kg IM, rab, guinea pigs-3-5 mg/kg IM , other rodents-4-8 mg/kg IM, budgies-10 mg/kg IM, ...
[PDF]UNIVERSITY OF CALIFORNIA, SAN DIEGO - iacuc
Xylazine HCl (Rompun). 5.0-10.01 / IP. (Light sedation , mild to mod analgesia). 1.0-5.01 / IM,. IP. (Light to heavy sedation, mild to mod analgesia). 1.0-5.01 / IM,.
"Xylazine and butorphanol: survey of field use in the horse" by ...
A field survey was made on the combined use of Xylazine and butorphanol for standing equine restraint (52 practitioner university clinics). A suggested initial ...
Guaifenesin-Ketamine-Xylazine Infusions to Provide Anesthesia in ...
Abstract. The purpose of this study was to determine a satisfactory combination of guaifenesin, ketamine, and Xylazine (GKX) that would produce safe and ...
Books on the term Xylazine
Anesthesia and Analgesia in Laboratory Animals
Richard Fish, Peggy J. Danneman, Marilyn Brown, 2011
1989); fentanyl–etomidate (De Wildt et al., 1983); etorphine– methotrimeprazine ( Small Animal Immobilon) (Flecknell et al., 1983); etorphine–acepromazine– atropine (Svendsen and Carter, 1985); and midazolam–Xylazine–alfentanil ...
Clinical Pharmacology
Cynthia Webster, 2001
The analgesic action of Xylazine is quite potent, especially in horses. The peripheral effects of Xylazine are related to blockage of a adrenergic receptors on vascular smooth muscle, or secondary to decreased sympathetic tone related to ...
Veterinary Pharmacology and Therapeutics
Jim E. Riviere, Mark G. Papich, 2013
Xylazine is often thought of as the prototypical (X2-adrenergic agonist; however, it does have one of the lowest Ot2:0ti affinities (see Table 13.1) and does not bind to imidazoline receptors. This higher affinity for OCradrenergic agonists may ...
Current Therapy in Equine Medicine
Norman Edward Robinson, Kim A. Sprayberry, 2009
... States for treatment of spasmodic colic. Of these medications, the most commonly used drugs for management of acute abdominal pain include Xylazine, butorphanol, the combination of dipyrone and hyoscine, and flunixin meglumine.
Veterinary Anesthesia and Pain Management Secrets
Stephen A. Greene, 2002
can be administered intramuscularly at a dose of 2 mg/kg of Xylazine plus 4-6 mg/ kg of ketamine. It is important not to antagonize the Xylazine too early (
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Blog posts on the term
Xylazine
Xylazine: The Zombie Maker - Michael's House Treatment Centers
www.michaelshouse.com/blog/xylazine-the-zombie-maker/
New Blog Post Xylazine Abuse in Puerto... - Behavioral Health Options | Facebook
New Blog Post Xylazine Abuse in Puerto Rico - Imagine an island where most people are addicts and you will have imagined Puerto Rico. Everything about...
www.facebook.com/BehavioralHealthOptions/posts/477197225674998
Xylazine abuse
Why are so many people abusing this in other countries? Besides the actual cutting reason, people seek this out separately as well. What is so great about this a2 agonist from any other?
www.bluelight.org/vb/threads/682985-Xylazine-abuse
Xylazine Horse Tranquilizer: The Next Zombie Drug? The Fix.com | Dr. Harris Stratyner, PhD - Psychologist
www.drharrisstratyner.com/xylazine-horse-tranquilizer-the-next-zombie-drug-the-fix-com/
The New “Death” Drug Filler Being Added to Illicit Drugs - GoodRx
www.goodrx.com/blog/the-new-death-drug-filler-being-added-to-illicit-drugs/
Dr Meducci vet's blog: Xylazine
drainameducci.blogspot.com/2011/05/xylazine.html
Xylazine - Drugs Forum
Xylazine Various drugs not covered by other forums
drugs-forum.com/forum/showthread.php?t=16978
Xylazine Abuse - Behavioral Health | Different Options for Rehab
Drug abuse can be found all over the world. In Puerto Rico, you will find a lot of Xylazine abuse going on. Better know as horse tranquilizers.
behavioralhealthoptions.com/blog/xylazine-abuse-in-puerto-rico/
Xylazine HCl Injection for Animal Use - Drugs.com
Learn about Xylazine HCl Injection for animal usage including: active ingredients, directions for use, precautions, and storage information.
www.drugs.com/vet/xylazine-hcl-injection.html
Xylazine - Drugs.com
Xylazine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Xylazine is available on the Drugs.com website.
www.drugs.com/international/xylazine.html
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